Parent Directory| Name | Size | Last Modified |
|---|---|---|
 0000874015-23-000105-index-headers.html | 2023-02-22 16:39:54 | |
| 0000874015-23-000105-index.html | 2023-02-22 16:39:54 | |
| 0000874015-23-000105.txt | 2023-02-22 16:39:54 | |
 0000874015-23-000105-xbrl.zip | 1898756 | 2023-02-22 16:39:54 |
| exhibit10-10.htm | 39692 | 2023-02-22 16:39:54 |
| exhibit10-13.htm | 31608 | 2023-02-22 16:39:54 |
| exhibit10-14.htm | 55999 | 2023-02-22 16:39:54 |
| exhibit10-16.htm | 84781 | 2023-02-22 16:39:54 |
| exhibit10-23.htm | 1142713 | 2023-02-22 16:39:54 |
| exhibit10-24.htm | 1309936 | 2023-02-22 16:39:54 |
| exhibit10-25.htm | 1622453 | 2023-02-22 16:39:54 |
| exhibit10-26.htm | 826479 | 2023-02-22 16:39:54 |
| exhibit10-27.htm | 307488 | 2023-02-22 16:39:54 |
| exhibit10-28.htm | 139887 | 2023-02-22 16:39:54 |
| exhibit10-29.htm | 148517 | 2023-02-22 16:39:54 |
| exhibit10-80.htm | 971167 | 2023-02-22 16:39:54 |
| exhibit10-81.htm | 324684 | 2023-02-22 16:39:54 |
| exhibit14.htm | 100962 | 2023-02-22 16:39:54 |
| exhibit21-1.htm | 4088 | 2023-02-22 16:39:54 |
| exhibit23-1.htm | 3312 | 2023-02-22 16:39:54 |
| exhibit31-1.htm | 12635 | 2023-02-22 16:39:54 |
| exhibit31-2.htm | 12643 | 2023-02-22 16:39:54 |
| exhibit32-1.htm | 7291 | 2023-02-22 16:39:54 |
| FilingSummary.xml | 51563 | 2023-02-22 16:39:54 |
| Financial_Report.xlsx | 184392 | 2023-02-22 16:39:54 |
| form10k.htm | 3560963 | 2023-02-22 16:39:54 |
| form10k_htm.xml | 2892042 | 2023-02-22 16:39:54 |
 image0.jpg | 168742 | 2023-02-22 16:39:54 |
 image07.jpg | 4712 | 2023-02-22 16:39:54 |
 image1.jpg | 34761 | 2023-02-22 16:39:54 |
 image11.jpg | 5123 | 2023-02-22 16:39:54 |
 image2.jpg | 131783 | 2023-02-22 16:39:54 |
 image3.jpg | 113867 | 2023-02-22 16:39:54 |
 image4.jpg | 94751 | 2023-02-22 16:39:54 |
 image5.jpg | 33280 | 2023-02-22 16:39:54 |
 image6.jpg | 53438 | 2023-02-22 16:39:54 |
 image7.jpg | 112488 | 2023-02-22 16:39:54 |
 image8.jpg | 30818 | 2023-02-22 16:39:54 |
| ions-20221231.xsd | 105455 | 2023-02-22 16:39:54 |
| ions-20221231_cal.xml | 149259 | 2023-02-22 16:39:54 |
| ions-20221231_def.xml | 684528 | 2023-02-22 16:39:54 |
| ions-20221231_lab.xml | 1598235 | 2023-02-22 16:39:54 |
| ions-20221231_pre.xml | 944165 | 2023-02-22 16:39:54 |
| MetaLinks.json | 1181126 | 2023-02-22 16:39:54 |
| R1.htm | 66049 | 2023-02-22 16:39:54 |
| R10.htm | 181265 | 2023-02-22 16:39:54 |
| R11.htm | 59980 | 2023-02-22 16:39:54 |
| R12.htm | 91831 | 2023-02-22 16:39:54 |
| R13.htm | 129057 | 2023-02-22 16:39:54 |
| R14.htm | 169509 | 2023-02-22 16:39:54 |
| R15.htm | 134198 | 2023-02-22 16:39:54 |
| R16.htm | 8735 | 2023-02-22 16:39:54 |
| R17.htm | 12536 | 2023-02-22 16:39:54 |
| R18.htm | 44441 | 2023-02-22 16:39:54 |
| R19.htm | 238332 | 2023-02-22 16:39:54 |
| R2.htm | 107654 | 2023-02-22 16:39:54 |
| R20.htm | 102553 | 2023-02-22 16:39:54 |
| R21.htm | 183035 | 2023-02-22 16:39:54 |
| R22.htm | 56778 | 2023-02-22 16:39:54 |
| R23.htm | 80026 | 2023-02-22 16:39:54 |
| R24.htm | 103456 | 2023-02-22 16:39:54 |
| R25.htm | 168975 | 2023-02-22 16:39:54 |
| R26.htm | 66457 | 2023-02-22 16:39:54 |
| R27.htm | 44039 | 2023-02-22 16:39:54 |
| R28.htm | 7249 | 2023-02-22 16:39:54 |
| R29.htm | 17399 | 2023-02-22 16:39:54 |
| R3.htm | 17768 | 2023-02-22 16:39:54 |
| R30.htm | 16309 | 2023-02-22 16:39:54 |
| R31.htm | 4623 | 2023-02-22 16:39:54 |
| R32.htm | 4328 | 2023-02-22 16:39:54 |
| R33.htm | 59104 | 2023-02-22 16:39:54 |
| R34.htm | 37632 | 2023-02-22 16:39:54 |
| R35.htm | 9411 | 2023-02-22 16:39:54 |
| R36.htm | 37907 | 2023-02-22 16:39:54 |
| R37.htm | 6125 | 2023-02-22 16:39:54 |
| R38.htm | 14583 | 2023-02-22 16:39:54 |
| R39.htm | 48517 | 2023-02-22 16:39:54 |
| R4.htm | 103493 | 2023-02-22 16:39:54 |
| R40.htm | 12008 | 2023-02-22 16:39:54 |
| R41.htm | 11341 | 2023-02-22 16:39:54 |
| R42.htm | 9101 | 2023-02-22 16:39:54 |
| R43.htm | 5074 | 2023-02-22 16:39:54 |
| R44.htm | 16354 | 2023-02-22 16:39:54 |
| R45.htm | 96935 | 2023-02-22 16:39:54 |
| R46.htm | 47407 | 2023-02-22 16:39:54 |
| R47.htm | 98289 | 2023-02-22 16:39:54 |
| R48.htm | 24744 | 2023-02-22 16:39:54 |
| R49.htm | 67932 | 2023-02-22 16:39:54 |
| R5.htm | 34302 | 2023-02-22 16:39:54 |
| R50.htm | 43325 | 2023-02-22 16:39:54 |
| R51.htm | 30888 | 2023-02-22 16:39:54 |
| R52.htm | 54436 | 2023-02-22 16:39:54 |
| R53.htm | 27586 | 2023-02-22 16:39:54 |
| R54.htm | 18977 | 2023-02-22 16:39:54 |
| R55.htm | 30801 | 2023-02-22 16:39:54 |
| R56.htm | 10008 | 2023-02-22 16:39:54 |
| R57.htm | 110646 | 2023-02-22 16:39:54 |
| R58.htm | 56164 | 2023-02-22 16:39:54 |
| R59.htm | 32453 | 2023-02-22 16:39:54 |
| R6.htm | 79248 | 2023-02-22 16:39:54 |
| R60.htm | 32444 | 2023-02-22 16:39:54 |
| R61.htm | 15791 | 2023-02-22 16:39:54 |
| R62.htm | 29749 | 2023-02-22 16:39:54 |
| R63.htm | 12367 | 2023-02-22 16:39:54 |
| R64.htm | 27864 | 2023-02-22 16:39:54 |
| R65.htm | 75378 | 2023-02-22 16:39:54 |
| R66.htm | 40369 | 2023-02-22 16:39:54 |
| R67.htm | 13567 | 2023-02-22 16:39:54 |
| R68.htm | 18133 | 2023-02-22 16:39:54 |
| R69.htm | 209364 | 2023-02-22 16:39:54 |
| R7.htm | 147385 | 2023-02-22 16:39:54 |
| R70.htm | 65651 | 2023-02-22 16:39:54 |
| R71.htm | 40659 | 2023-02-22 16:39:54 |
| R72.htm | 69905 | 2023-02-22 16:39:54 |
| R73.htm | 66777 | 2023-02-22 16:39:54 |
| R74.htm | 5557 | 2023-02-22 16:39:54 |
| R75.htm | 13960 | 2023-02-22 16:39:54 |
| R76.htm | 13228 | 2023-02-22 16:39:54 |
| R77.htm | 32747 | 2023-02-22 16:39:54 |
| R78.htm | 10086 | 2023-02-22 16:39:54 |
| R79.htm | 11473 | 2023-02-22 16:39:54 |
| R8.htm | 10772 | 2023-02-22 16:39:54 |
| R80.htm | 112227 | 2023-02-22 16:39:54 |
| R9.htm | 191254 | 2023-02-22 16:39:54 |
| report.css | 2768 | 2023-02-22 16:39:54 |
| Show.js | 1086 | 2023-02-22 16:39:54 |