Stockholders' Equity, Stock-based Compensation Expense (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2022	Dec. 31, 2021	Dec. 31, 2020	Oct. 31, 2020
Stock-Based Compensation [Abstract]
Stock-based compensation expense	$ 100,264	$ 120,678	$ 230,117
Cost of Sales [Member]
Stock-Based Compensation [Abstract]
Stock-based compensation expense	533	456	1,991
Research, Development and Patent [Member]
Stock-Based Compensation [Abstract]
Stock-based compensation expense	73,704	87,522	115,584
Selling, General and Administrative [Member]
Stock-Based Compensation [Abstract]
Stock-based compensation expense	$ 26,027	$ 32,700	$ 112,542
Akcea [Member]
Stock-Based Compensation [Abstract]
Unrecognized compensation cost related to non-vested units				$ 59,300