Income Taxes, Deferred Tax Assets and Liabilities (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2022	Dec. 31, 2021
Deferred Tax Assets [Abstract]
Net operating loss carryovers	$ 87,802	$ 85,600
Tax credits	277,436	269,538
Deferred revenue	85,700	104,330
Stock-based compensation	86,983	86,611
Intangible and capital assets	104,649	92,542
Convertible debt	34,384	45,681
Interest expense limitation	0	6,996
Capitalized research and development expenses	119,635	0
Long-term lease liabilities	45,612	5,119
Other	15,813	9,929
Total deferred tax assets	858,014	706,346
Deferred Tax Liabilities [Abstract]
Fixed assets	(4,475)	(3,303)
Right-of-use assets	(44,504)	(4,159)
Other	(313)	(1,111)
Net deferred tax asset	808,722	697,773
Valuation allowance	(808,722)	(697,773)
Total net deferred tax assets and liabilities	0	$ 0
Increase in valuation allowance	$ 111,000