Organization and Significant Accounting Policies, Accrued Liabilities (Details) - USD ($) $ in Thousands	Dec. 31, 2022	Dec. 31, 2021
Accrued Liabilities [Abstract]
Clinical expenses	$ 116,460	$ 65,730
In-licensing expenses	7,945	8,044
Commercial expenses	3,498	2,471
Other miscellaneous expenses	12,198	12,315
Total accrued liabilities	$ 140,101	$ 88,560