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For an entity that discloses a concentration risk in relation to quantitative amount, which serves as the "benchmark" (or denominator) in the equation, this concept represents the concentration percentage derived from the division.

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Collaborative Arrangements and Licensing Agreements, Alnylam Pharmaceuticals, Inc. (Details) $ in Thousands	3 Months Ended	12 Months Ended
	Dec. 31, 2020 USD ($)	Dec. 31, 2022 USD ($)	Dec. 31, 2021 USD ($)	Dec. 31, 2020 USD ($)	Dec. 31, 2015 Target Program
Collaborative Arrangement and Licensing Agreement [Abstract]
Revenue		$ 587,367	$ 810,456	$ 729,264
R&D Revenue [Member]
Collaborative Arrangement and Licensing Agreement [Abstract]
Revenue		284,009	468,061	$ 364,565
Alnylam [Member]
Collaborative Arrangement and Licensing Agreement [Abstract]
Number of therapeutic programs \| Program					4
Number of therapeutic targets granted to Ionis \| Target					4
Number of unnamed therapeutic targets granted to Ionis \| Target					2
Number of therapeutic targets granted by Ionis \| Target					4
Award from arbitration panel	$ 41,200
Revenue	$ 41,200
Deferred revenue		$ 0	$ 0
Alnylam [Member] \| Revenue [Member] \| Strategic Partner [Member]
Collaborative Arrangement and Licensing Agreement [Abstract]
Concentration percentage		4.00%	0.00%	7.00%
Alnylam [Member] \| R&D Revenue [Member]
Collaborative Arrangement and Licensing Agreement [Abstract]
Revenue		$ 21,400	$ 0	$ 47,900