Long-Term Obligations and Commitments, Operating Leases (Details) $ in Thousands	1 Months Ended		12 Months Ended
	Sep. 30, 2022 Lease	Jan. 31, 2022 USD ($)	Dec. 31, 2022 USD ($) Option Lot	Dec. 31, 2021 USD ($)	Dec. 31, 2020 USD ($)
Operating Leases [Abstract]
Lease payments to be made over initial term of lease			$ 299,594
Right-of-use operating lease assets			181,544	$ 17,974
Operating lease liabilities			$ 186,156	22,058
Weighted average remaining lease term			13 years 9 months 18 days
Weighted average discount rate			6.90%
Operating lease cash payments			$ 4,000	$ 3,300	$ 3,800
Carlsbad Facility [Member]
Operating Leases [Abstract]
Number of options to extend lease | Option			1
Term of lease extension			5 years
Carlsbad Office Spaces [Member]
Operating Leases [Abstract]
Number of leases that were extended | Lease	1
Number of options to extend lease | Option			0
Headquarters Location in Carlsbad, California [Member]
Operating Leases [Abstract]
Initial term of operating lease			15 years
Number of options to extend lease | Option			2
Term of lease extension			5 years
Lease payments to be made over initial term of lease			$ 280,000
Number of lots of undeveloped land included in purchase and sale agreement | Lot			2
Development Chemistry and Manufacturing Facility in Oceanside, California [Member]
Operating Leases [Abstract]
Initial term of operating lease			20 years 3 months
Number of options to extend lease | Option			2
Term of lease extension			10 years
Boston Office Space [Member]
Operating Leases [Abstract]
Initial term of operating lease			123 months
Term of lease extension			5 years
Period of free rent under lease			3 months
Subleased Office Space in Boston [Member]
Operating Leases [Abstract]
Term of sublease		83 months
Period of free rent under sublease		7 months
Lease payments to be received over term of sublease		$ 9,600
Another Office Space in Boston [Member]
Operating Leases [Abstract]
Initial term of operating lease			91 months
Number of options to extend lease | Option			1
Term of lease extension			5 years
Period of free rent under lease			7 months
Lease payments to be made over initial term of lease			$ 6,800