Parent Directory| Name | Size | Last Modified |
|---|---|---|
 0000874015-21-000056-index-headers.html | 2021-02-24 15:34:10 | |
| 0000874015-21-000056-index.html | 2021-02-24 15:34:10 | |
| 0000874015-21-000056.txt | 2021-02-24 15:34:10 | |
 0000874015-21-000056-xbrl.zip | 1461563 | 2021-02-24 15:34:10 |
| exhibit10_18.htm | 82833 | 2021-02-24 15:34:10 |
| exhibit10_46.htm | 592701 | 2021-02-24 15:34:10 |
| exhibit10_56.htm | 37595 | 2021-02-24 15:34:10 |
| exhibit10_61.htm | 46168 | 2021-02-24 15:34:10 |
| exhibit10_79.htm | 13850 | 2021-02-24 15:34:10 |
| exhibit10_80.htm | 68105 | 2021-02-24 15:34:10 |
| exhibit10_81.htm | 72885 | 2021-02-24 15:34:10 |
| exhibit21_1.htm | 3062 | 2021-02-24 15:34:10 |
| exhibit23_1.htm | 4117 | 2021-02-24 15:34:10 |
| exhibit31_1.htm | 13248 | 2021-02-24 15:34:10 |
| exhibit31_2.htm | 13256 | 2021-02-24 15:34:10 |
| exhibit32_1.htm | 7693 | 2021-02-24 15:34:10 |
| FilingSummary.xml | 56278 | 2021-02-24 15:34:10 |
| Financial_Report.xlsx | 176892 | 2021-02-24 15:34:10 |
| form10k.htm | 4240904 | 2021-02-24 15:34:10 |
| form10k_htm.xml | 3941828 | 2021-02-24 15:34:10 |
 image00018.jpg | 112488 | 2021-02-24 15:34:10 |
 image01.jpg | 367995 | 2021-02-24 15:34:10 |
 image02.jpg | 46106 | 2021-02-24 15:34:10 |
 image04.jpg | 31669 | 2021-02-24 15:34:10 |
 image05.jpg | 25608 | 2021-02-24 15:34:10 |
 image06.jpg | 24762 | 2021-02-24 15:34:10 |
 image08.jpg | 110291 | 2021-02-24 15:34:10 |
 image09.jpg | 31066 | 2021-02-24 15:34:10 |
 image10.jpg | 112405 | 2021-02-24 15:34:10 |
 image11.jpg | 936705 | 2021-02-24 15:34:10 |
 image12.jpg | 129410 | 2021-02-24 15:34:10 |
 image13.jpg | 41580 | 2021-02-24 15:34:10 |
 image15.jpg | 9650 | 2021-02-24 15:34:10 |
 image17.jpg | 3544 | 2021-02-24 15:34:10 |
 image4.jpg | 64758 | 2021-02-24 15:34:10 |
 image5.jpg | 87380 | 2021-02-24 15:34:10 |
 image7.jpg | 105188 | 2021-02-24 15:34:10 |
| ions-20201231.xsd | 113101 | 2021-02-24 15:34:10 |
| ions-20201231_cal.xml | 142781 | 2021-02-24 15:34:10 |
| ions-20201231_def.xml | 794894 | 2021-02-24 15:34:10 |
| ions-20201231_lab.xml | 1674558 | 2021-02-24 15:34:10 |
| ions-20201231_pre.xml | 1048457 | 2021-02-24 15:34:10 |
| MetaLinks.json | 1122538 | 2021-02-24 15:34:10 |
| R1.htm | 58940 | 2021-02-24 15:34:10 |
| R10.htm | 324802 | 2021-02-24 15:34:10 |
| R11.htm | 150204 | 2021-02-24 15:34:10 |
| R12.htm | 106858 | 2021-02-24 15:34:10 |
| R13.htm | 145386 | 2021-02-24 15:34:10 |
| R14.htm | 171026 | 2021-02-24 15:34:10 |
| R15.htm | 200465 | 2021-02-24 15:34:10 |
| R16.htm | 19569 | 2021-02-24 15:34:10 |
| R17.htm | 16473 | 2021-02-24 15:34:10 |
| R18.htm | 119644 | 2021-02-24 15:34:10 |
| R19.htm | 8734 | 2021-02-24 15:34:10 |
| R2.htm | 104166 | 2021-02-24 15:34:10 |
| R20.htm | 7649 | 2021-02-24 15:34:10 |
| R21.htm | 78457 | 2021-02-24 15:34:10 |
| R22.htm | 380188 | 2021-02-24 15:34:10 |
| R23.htm | 226207 | 2021-02-24 15:34:10 |
| R24.htm | 151572 | 2021-02-24 15:34:10 |
| R25.htm | 97218 | 2021-02-24 15:34:10 |
| R26.htm | 123990 | 2021-02-24 15:34:10 |
| R27.htm | 168566 | 2021-02-24 15:34:10 |
| R28.htm | 101459 | 2021-02-24 15:34:10 |
| R29.htm | 14821 | 2021-02-24 15:34:10 |
| R3.htm | 17618 | 2021-02-24 15:34:10 |
| R30.htm | 15130 | 2021-02-24 15:34:10 |
| R31.htm | 114166 | 2021-02-24 15:34:10 |
| R32.htm | 78335 | 2021-02-24 15:34:10 |
| R33.htm | 5597 | 2021-02-24 15:34:10 |
| R34.htm | 70644 | 2021-02-24 15:34:10 |
| R35.htm | 74239 | 2021-02-24 15:34:10 |
| R36.htm | 4279 | 2021-02-24 15:34:10 |
| R37.htm | 4654 | 2021-02-24 15:34:10 |
| R38.htm | 32300 | 2021-02-24 15:34:10 |
| R39.htm | 12927 | 2021-02-24 15:34:10 |
| R4.htm | 90129 | 2021-02-24 15:34:10 |
| R40.htm | 9489 | 2021-02-24 15:34:10 |
| R41.htm | 19616 | 2021-02-24 15:34:10 |
| R42.htm | 17007 | 2021-02-24 15:34:10 |
| R43.htm | 37792 | 2021-02-24 15:34:10 |
| R44.htm | 4982 | 2021-02-24 15:34:10 |
| R45.htm | 5974 | 2021-02-24 15:34:10 |
| R46.htm | 35136 | 2021-02-24 15:34:10 |
| R47.htm | 7901 | 2021-02-24 15:34:10 |
| R48.htm | 5864 | 2021-02-24 15:34:10 |
| R49.htm | 4987 | 2021-02-24 15:34:10 |
| R5.htm | 30653 | 2021-02-24 15:34:10 |
| R50.htm | 65467 | 2021-02-24 15:34:10 |
| R51.htm | 21674 | 2021-02-24 15:34:10 |
| R52.htm | 83155 | 2021-02-24 15:34:10 |
| R53.htm | 22309 | 2021-02-24 15:34:10 |
| R54.htm | 22869 | 2021-02-24 15:34:10 |
| R55.htm | 86624 | 2021-02-24 15:34:10 |
| R56.htm | 14200 | 2021-02-24 15:34:10 |
| R57.htm | 19240 | 2021-02-24 15:34:10 |
| R58.htm | 27790 | 2021-02-24 15:34:10 |
| R59.htm | 68729 | 2021-02-24 15:34:10 |
| R6.htm | 86392 | 2021-02-24 15:34:10 |
| R60.htm | 30785 | 2021-02-24 15:34:10 |
| R61.htm | 9861 | 2021-02-24 15:34:10 |
| R62.htm | 85436 | 2021-02-24 15:34:10 |
| R63.htm | 55169 | 2021-02-24 15:34:10 |
| R64.htm | 32311 | 2021-02-24 15:34:10 |
| R65.htm | 19652 | 2021-02-24 15:34:10 |
| R66.htm | 42397 | 2021-02-24 15:34:10 |
| R67.htm | 11291 | 2021-02-24 15:34:10 |
| R68.htm | 27361 | 2021-02-24 15:34:10 |
| R69.htm | 86432 | 2021-02-24 15:34:10 |
| R7.htm | 8162 | 2021-02-24 15:34:10 |
| R70.htm | 34605 | 2021-02-24 15:34:10 |
| R71.htm | 13702 | 2021-02-24 15:34:10 |
| R72.htm | 16192 | 2021-02-24 15:34:10 |
| R73.htm | 212186 | 2021-02-24 15:34:10 |
| R74.htm | 103304 | 2021-02-24 15:34:10 |
| R75.htm | 62759 | 2021-02-24 15:34:10 |
| R76.htm | 40754 | 2021-02-24 15:34:10 |
| R77.htm | 42907 | 2021-02-24 15:34:10 |
| R78.htm | 71122 | 2021-02-24 15:34:10 |
| R79.htm | 54403 | 2021-02-24 15:34:10 |
| R8.htm | 129384 | 2021-02-24 15:34:10 |
| R80.htm | 42638 | 2021-02-24 15:34:10 |
| R81.htm | 70174 | 2021-02-24 15:34:10 |
| R82.htm | 25047 | 2021-02-24 15:34:10 |
| R83.htm | 48399 | 2021-02-24 15:34:10 |
| R84.htm | 21464 | 2021-02-24 15:34:10 |
| R85.htm | 69271 | 2021-02-24 15:34:10 |
| R86.htm | 10915 | 2021-02-24 15:34:10 |
| R87.htm | 10177 | 2021-02-24 15:34:10 |
| R88.htm | 102448 | 2021-02-24 15:34:10 |
| R9.htm | 7923 | 2021-02-24 15:34:10 |
| report.css | 2768 | 2021-02-24 15:34:10 |
| Show.js | 1086 | 2021-02-24 15:34:10 |