Organization and Significant Accounting Policies, Accrued Liabilities (Details) - USD ($) $ in Thousands	Dec. 31, 2020	Dec. 31, 2019
Accrued Liabilities [Abstract]
Clincial expenses	$ 39,477	$ 24,461
In-licensing expenses	8,264	10,289
Commercial expenses	11,559	6,020
Other miscellaneous expenses	30,861	25,999
Total accrued liabilities	$ 90,161	$ 66,769