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Akcea Acquisition (Details) - USD ($)
$ / shares in Units, shares in Millions, $ in Millions
1 Months Ended 3 Months Ended
Oct. 31, 2020
Dec. 31, 2020
Sep. 30, 2020
Jun. 30, 2017
Severance and Retention Related to Akcea Acquisition [Member]        
Severance and Retention Costs [Abstract]        
Beginning balance $ 0.0 $ 0.0    
Severance and retention expense   15.3    
Amounts paid during the period   (0.6)    
Severance and Retention Related to Akcea Acquisition [Member] | Accrued Compensation [Member]        
Severance and Retention Costs [Abstract]        
Ending balance   14.7    
Severance and Retention Related to Akcea Acquisition [Member] | R&D Expenses [Member]        
Severance and Retention Costs [Abstract]        
Severance and retention expense   3.9    
Severance and Retention Related to Akcea Acquisition [Member] | SG&A Expenses [Member]        
Severance and Retention Costs [Abstract]        
Severance and retention expense   11.4    
Severance Related to Akcea Acquisition [Member] | Maximum [Member]        
Severance and Retention Costs [Abstract]        
Expected expenses   9.3    
Retention Related to Akcea Acquisition [Member] | Maximum [Member]        
Severance and Retention Costs [Abstract]        
Expected expenses   19.2    
Akcea [Member]        
Akcea Acquisition [Abstract]        
Percentage ownership 100.00%   76.00% 100.00%
Shares purchased (in shares) 24.8      
Purchase price per share (in dollars per share) $ 18.15      
Purchase price $ 450.6      
Direct transaction costs   $ 40.6    
Cash purchase price of equity awards (in dollars per share)   $ 18.15    
Payments for cancelled equity awards   $ 53.4    
Unrecognized compensation cost related to non-vested RSUs $ 59.3      
Akcea [Member] | Maximum [Member]        
Akcea Acquisition [Abstract]        
Percentage ownership 77.00%