Organization and Significant Accounting Policies, Research, Development and Patent Expenses (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2020	Dec. 31, 2019	Dec. 31, 2018
Research, Development and Patent Expenses [Abstract]
Research and development expenses	$ 531,000	$ 461,500	$ 411,900
Estimated Amortization Expense [Abstract]
Non-cash charges related to write-down	1,948	2,226	802
Patents [Member]
Research, Development and Patent Expenses [Abstract]
Research and development expenses	$ 4,100	4,200	2,600
Estimated useful life	10 years 3 months 18 days
Cost	$ 37,000	34,000
Accumulated amortization	9,100	8,300
Estimated Amortization Expense [Abstract]
2021	2,100
2022	2,000
2023	1,900
2024	1,700
2025	1,600
Non-cash charges related to write-down	1,900	2,200	800
Collaborative Agreements [Member]
Research, Development and Patent Expenses [Abstract]
Research and development expenses	$ 49,800	$ 83,200	$ 58,700