Parent Directory| Name | Size | Last Modified |
|---|---|---|
 0000874015-16-000112-index-headers.html | 2016-02-25 19:08:02 | |
| 0000874015-16-000112-index.html | 2016-02-25 19:08:02 | |
| 0000874015-16-000112.txt | 2016-02-25 19:08:02 | |
 0000874015-16-000112-xbrl.zip | 354692 | 2016-02-25 19:08:02 |
| ex10_64.htm | 18393 | 2016-02-25 19:08:02 |
| exhibit21_1.htm | 2130 | 2016-02-25 19:08:02 |
| exhibit23_1.htm | 4957 | 2016-02-25 19:08:02 |
| exhibit31_1.htm | 12435 | 2016-02-25 19:08:02 |
| exhibit31_2.htm | 12428 | 2016-02-25 19:08:02 |
| exhibit32_1.htm | 6977 | 2016-02-25 19:08:02 |
| FilingSummary.xml | 50941 | 2016-02-25 19:08:02 |
| Financial_Report.xlsx | 138645 | 2016-02-25 19:08:02 |
| form10k.htm | 2612450 | 2016-02-25 19:08:02 |
 image00002.jpg | 112488 | 2016-02-25 19:08:02 |
 image00004.jpg | 714 | 2016-02-25 19:08:02 |
 image00015.jpg | 33692 | 2016-02-25 19:08:02 |
 image00016.jpg | 129581 | 2016-02-25 19:08:02 |
 image00017.jpg | 46168 | 2016-02-25 19:08:02 |
 image00018.jpg | 72437 | 2016-02-25 19:08:02 |
 image00019.jpg | 33252 | 2016-02-25 19:08:02 |
 image00020.jpg | 66324 | 2016-02-25 19:08:02 |
 image00021.jpg | 18221 | 2016-02-25 19:08:02 |
 image00022.jpg | 28664 | 2016-02-25 19:08:02 |
 image00023.jpg | 20225 | 2016-02-25 19:08:02 |
 image00024.jpg | 37223 | 2016-02-25 19:08:02 |
 image00025.jpg | 68776 | 2016-02-25 19:08:02 |
 image10.jpg | 46106 | 2016-02-25 19:08:02 |
 image11.jpg | 17854 | 2016-02-25 19:08:02 |
 image12.jpg | 31669 | 2016-02-25 19:08:02 |
 image13.jpg | 25608 | 2016-02-25 19:08:02 |
 image14.jpg | 24762 | 2016-02-25 19:08:02 |
| ions-20151231.xml | 2758958 | 2016-02-25 19:08:02 |
| ions-20151231.xsd | 103013 | 2016-02-25 19:08:02 |
| ions-20151231_cal.xml | 114068 | 2016-02-25 19:08:02 |
| ions-20151231_def.xml | 866251 | 2016-02-25 19:08:02 |
| ions-20151231_lab.xml | 1412487 | 2016-02-25 19:08:02 |
| ions-20151231_pre.xml | 1027859 | 2016-02-25 19:08:02 |
| R1.htm | 28243 | 2016-02-25 19:08:02 |
| R10.htm | 196357 | 2016-02-25 19:08:02 |
| R11.htm | 141462 | 2016-02-25 19:08:02 |
| R12.htm | 96891 | 2016-02-25 19:08:02 |
| R13.htm | 88651 | 2016-02-25 19:08:02 |
| R14.htm | 122785 | 2016-02-25 19:08:02 |
| R15.htm | 84053 | 2016-02-25 19:08:02 |
| R16.htm | 66121 | 2016-02-25 19:08:02 |
| R17.htm | 6240 | 2016-02-25 19:08:02 |
| R18.htm | 7100 | 2016-02-25 19:08:02 |
| R19.htm | 85821 | 2016-02-25 19:08:02 |
| R2.htm | 73686 | 2016-02-25 19:08:02 |
| R20.htm | 239176 | 2016-02-25 19:08:02 |
| R21.htm | 123980 | 2016-02-25 19:08:02 |
| R22.htm | 141666 | 2016-02-25 19:08:02 |
| R23.htm | 92620 | 2016-02-25 19:08:02 |
| R24.htm | 74388 | 2016-02-25 19:08:02 |
| R25.htm | 121642 | 2016-02-25 19:08:02 |
| R26.htm | 65111 | 2016-02-25 19:08:02 |
| R27.htm | 84532 | 2016-02-25 19:08:02 |
| R28.htm | 9219 | 2016-02-25 19:08:02 |
| R29.htm | 99897 | 2016-02-25 19:08:02 |
| R3.htm | 19686 | 2016-02-25 19:08:02 |
| R30.htm | 34046 | 2016-02-25 19:08:02 |
| R31.htm | 5021 | 2016-02-25 19:08:02 |
| R32.htm | 37507 | 2016-02-25 19:08:02 |
| R33.htm | 4653 | 2016-02-25 19:08:02 |
| R34.htm | 5874 | 2016-02-25 19:08:02 |
| R35.htm | 25290 | 2016-02-25 19:08:02 |
| R36.htm | 13283 | 2016-02-25 19:08:02 |
| R37.htm | 69460 | 2016-02-25 19:08:02 |
| R38.htm | 13272 | 2016-02-25 19:08:02 |
| R39.htm | 26872 | 2016-02-25 19:08:02 |
| R4.htm | 44349 | 2016-02-25 19:08:02 |
| R40.htm | 107494 | 2016-02-25 19:08:02 |
| R41.htm | 19487 | 2016-02-25 19:08:02 |
| R42.htm | 79722 | 2016-02-25 19:08:02 |
| R43.htm | 32453 | 2016-02-25 19:08:02 |
| R44.htm | 27892 | 2016-02-25 19:08:02 |
| R45.htm | 42554 | 2016-02-25 19:08:02 |
| R46.htm | 30632 | 2016-02-25 19:08:02 |
| R47.htm | 32864 | 2016-02-25 19:08:02 |
| R48.htm | 76547 | 2016-02-25 19:08:02 |
| R49.htm | 55134 | 2016-02-25 19:08:02 |
| R5.htm | 14598 | 2016-02-25 19:08:02 |
| R50.htm | 32375 | 2016-02-25 19:08:02 |
| R51.htm | 12136 | 2016-02-25 19:08:02 |
| R52.htm | 20560 | 2016-02-25 19:08:02 |
| R53.htm | 40730 | 2016-02-25 19:08:02 |
| R54.htm | 53348 | 2016-02-25 19:08:02 |
| R55.htm | 36673 | 2016-02-25 19:08:02 |
| R56.htm | 15777 | 2016-02-25 19:08:02 |
| R57.htm | 16230 | 2016-02-25 19:08:02 |
| R58.htm | 75254 | 2016-02-25 19:08:02 |
| R59.htm | 49274 | 2016-02-25 19:08:02 |
| R6.htm | 49239 | 2016-02-25 19:08:02 |
| R60.htm | 25552 | 2016-02-25 19:08:02 |
| R61.htm | 28475 | 2016-02-25 19:08:02 |
| R62.htm | 61684 | 2016-02-25 19:08:02 |
| R63.htm | 53011 | 2016-02-25 19:08:02 |
| R64.htm | 26016 | 2016-02-25 19:08:02 |
| R65.htm | 64792 | 2016-02-25 19:08:02 |
| R66.htm | 31715 | 2016-02-25 19:08:02 |
| R67.htm | 54179 | 2016-02-25 19:08:02 |
| R68.htm | 32959 | 2016-02-25 19:08:02 |
| R69.htm | 38498 | 2016-02-25 19:08:02 |
| R7.htm | 9468 | 2016-02-25 19:08:02 |
| R70.htm | 15108 | 2016-02-25 19:08:02 |
| R71.htm | 24971 | 2016-02-25 19:08:02 |
| R72.htm | 49146 | 2016-02-25 19:08:02 |
| R73.htm | 28431 | 2016-02-25 19:08:02 |
| R74.htm | 18665 | 2016-02-25 19:08:02 |
| R75.htm | 43292 | 2016-02-25 19:08:02 |
| R76.htm | 68620 | 2016-02-25 19:08:02 |
| R77.htm | 8426 | 2016-02-25 19:08:02 |
| R78.htm | 75084 | 2016-02-25 19:08:02 |
| R8.htm | 116693 | 2016-02-25 19:08:02 |
| R9.htm | 14528 | 2016-02-25 19:08:02 |
| report.css | 2768 | 2016-02-25 19:08:02 |
| Show.js | 1411 | 2016-02-25 19:08:02 |