Collaborative Arrangements and Licensing Agreements, Intellectual Property Sale and Licensing Agreements (Details) - USD ($)	1 Months Ended	3 Months Ended								12 Months Ended
	Jan. 31, 2009	Dec. 31, 2015	Sep. 30, 2015	Jun. 30, 2015	Mar. 31, 2015	Dec. 31, 2014	Sep. 30, 2014	Jun. 30, 2014	Mar. 31, 2014	Dec. 31, 2015	Dec. 31, 2014	Dec. 31, 2013
Collaborative Arrangement and Licensing Agreement [Abstract]
Revenue earned		$ 51,571,000	$ 49,121,000	$ 120,428,000	$ 62,583,000	$ 84,861,000	$ 44,063,000	$ 57,076,000	$ 28,161,000	$ 283,703,000	$ 214,161,000	$ 147,285,000
Abbott Molecular Inc. [Member]
Collaborative Arrangement and Licensing Agreement [Abstract]
Sales price of interest owned in subsidiary	$ 215,000,000
Revenue earned										0	$ 0	$ 0
Abbott Molecular Inc. [Member] | Minimum [Member]
Collaborative Arrangement and Licensing Agreement [Abstract]
Cumulative net sales threshold used to calculate earn out payments										$ 140,000,000
Percentage of cumulative net sales used to calculate earn out payments, over $140 million and up to $2.1 billion										2.50%
Percentage of cumulative net sales used to calculate earn out payments, over $2.1 billion										1.50%
Abbott Molecular Inc. [Member] | Maximum [Member]
Collaborative Arrangement and Licensing Agreement [Abstract]
Cumulative net sales threshold used to calculate earn out payments										$ 2,100,000,000
Revenue threshold used to calculate earn out payments										$ 50,000,000
Percentage of cumulative net sales used to calculate earn out payments, over $140 million and up to $2.1 billion										5.00%
Percentage of cumulative net sales used to calculate earn out payments, over $2.1 billion										3.00%
University of Massachusetts [Member] | In-Licensing Arrangement [Member]
Collaborative Arrangement and Licensing Agreement [Abstract]
Maximum amount of milestone payments payable		300,000								$ 300,000
Verva Pharmaceuticals Ltd. [Member] | In-Licensing Arrangement [Member]
Collaborative Arrangement and Licensing Agreement [Abstract]
Maximum amount of milestone payments payable		6,100,000								6,100,000
Cold Spring Harbor Laboratory [Member] | In-Licensing Arrangement [Member]
Collaborative Arrangement and Licensing Agreement [Abstract]
Maximum amount of sublicense revenue and post licensing milestone payments payable under in-licensing arrangement		$ 11,300,000								$ 11,300,000