Collaborative Arrangements and Licensing Agreements, Satellite Company Collaborations - Antisense Therapeutics Limited (Details) - USD ($)	3 Months Ended								12 Months Ended
	Dec. 31, 2015	Sep. 30, 2015	Jun. 30, 2015	Mar. 31, 2015	Dec. 31, 2014	Sep. 30, 2014	Jun. 30, 2014	Mar. 31, 2014	Dec. 31, 2015	Dec. 31, 2014	Dec. 31, 2013
Collaborative Arrangement and Licensing Agreement [Abstract]
Revenue earned	$ 51,571,000	$ 49,121,000	$ 120,428,000	$ 62,583,000	$ 84,861,000	$ 44,063,000	$ 57,076,000	$ 28,161,000	$ 283,703,000	$ 214,161,000	$ 147,285,000
Antisense Therapeutics Limited [Member] | Satellite Company Collaborative Arrangement and Licensing Agreement [Member]
Collaborative Arrangement and Licensing Agreement [Abstract]
Revenue earned									$ 0	$ 0	$ 0
Antisense Therapeutics Limited [Member] | Satellite Company Collaborative Arrangement and Licensing Agreement [Member] | Maximum [Member]
Collaborative Arrangement and Licensing Agreement [Abstract]
Ownership interest percentage	10.00%				10.00%				10.00%	10.00%