Collaborative Arrangements and Licensing Agreements, Satellite Company Collaborations - Atlantic Pharmaceuticals Limited (Details) - USD ($) $ in Thousands		1 Months Ended	3 Months Ended								12 Months Ended
		Mar. 31, 2007	Dec. 31, 2015	Sep. 30, 2015	Jun. 30, 2015	Mar. 31, 2015	Dec. 31, 2014	Sep. 30, 2014	Jun. 30, 2014	Mar. 31, 2014	Dec. 31, 2015	Dec. 31, 2014	Dec. 31, 2013
Collaborative Arrangement and Licensing Agreement [Abstract]
Revenue earned			$ 51,571	$ 49,121	$ 120,428	$ 62,583	$ 84,861	$ 44,063	$ 57,076	$ 28,161	$ 283,703	$ 214,161	$ 147,285
Atlantic Pharmaceuticals Limited [Member] | Satellite Company Collaborative Arrangement and Licensing Agreement [Member]
Collaborative Arrangement and Licensing Agreement [Abstract]
Upfront fee in the form of equity securities		$ 2,000
Next potential milestone			$ 600								$ 600
Ownership interest percentage			11.00%				12.00%				11.00%	12.00%
Royalties earned and paid in equity													$ 700
Revenue earned	[1]
Atlantic Pharmaceuticals Limited [Member] | Satellite Company Collaborative Arrangement and Licensing Agreement [Member] | Regulatory Milestones [Member]
Collaborative Arrangement and Licensing Agreement [Abstract]
Maximum amount of payments receivable			$ 1,400								$ 1,400

[1] Revenue from this relationship was negligible for the year.