Income Taxes, Deferred Tax Assets and Liabilities (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2015	Dec. 31, 2014
Deferred Tax Assets [Abstract]
Net operating loss carryovers	$ 218,493	$ 231,654
R&D credits	153,601	93,594
Deferred revenue	45,110	58,836
Stock-based compensation	31,093	21,553
Other	19,655	15,549
Total deferred tax assets	467,952	421,186
Deferred Tax Liabilities [Abstract]
Convertible debt	(55,928)	(73,733)
Unrealized gain in other comprehensive income	(5,288)	(27,878)
Intangible and capital assets	(2,643)	(3,641)
Net deferred tax asset	404,093	315,934
Valuation allowance	(404,093)	(315,934)
Net deferreds	0	0
Excess tax benefits from shared-based compensation awards	396	$ 1,463
Unrealized excess tax benefits associated with share-based compensation	$ 76,900