Parent Directory| Name | Size | Last Modified |
|---|---|---|
 0001104659-14-015019-index-headers.html | 2014-02-28 18:49:45 | |
| 0001104659-14-015019-index.html | 2014-02-28 18:49:45 | |
| 0001104659-14-015019.txt | 2014-02-28 18:49:45 | |
 0001104659-14-015019-xbrl.zip | 342848 | 2014-02-28 18:49:45 |
| a13-24781_110k.htm | 2757479 | 2014-02-28 18:49:45 |
| a13-24781_1ex21d1.htm | 2145 | 2014-02-28 18:49:45 |
| a13-24781_1ex23d1.htm | 4455 | 2014-02-28 18:49:45 |
| a13-24781_1ex31d1.htm | 12045 | 2014-02-28 18:49:45 |
| a13-24781_1ex31d2.htm | 12143 | 2014-02-28 18:49:45 |
| a13-24781_1ex32d1.htm | 7432 | 2014-02-28 18:49:45 |
| FilingSummary.xml | 35606 | 2014-02-28 18:49:45 |
| Financial_Report.xls | 2985474 | 2014-02-28 18:49:45 |
| Financial_Report.xlsx | 301373 | 2014-02-28 18:49:45 |
 g247811eai001.jpg | 39585 | 2014-02-28 18:49:45 |
 g247811eai002.gif | 59889 | 2014-02-28 18:49:45 |
 g247811egi001.gif | 4665 | 2014-02-28 18:49:45 |
 g247811eki001.gif | 6591 | 2014-02-28 18:49:45 |
| isis-20131231.xml | 2851431 | 2014-02-28 18:49:45 |
| isis-20131231.xsd | 98995 | 2014-02-28 18:49:45 |
| isis-20131231_cal.xml | 124290 | 2014-02-28 18:49:45 |
| isis-20131231_def.xml | 527747 | 2014-02-28 18:49:45 |
| isis-20131231_lab.xml | 1577785 | 2014-02-28 18:49:45 |
| isis-20131231_pre.xml | 781628 | 2014-02-28 18:49:45 |
| R1.htm | 37258 | 2014-02-28 18:49:45 |
| R10.htm | 240906 | 2014-02-28 18:49:45 |
| R11.htm | 88387 | 2014-02-28 18:49:45 |
| R12.htm | 134055 | 2014-02-28 18:49:45 |
| R13.htm | 154800 | 2014-02-28 18:49:45 |
| R14.htm | 96759 | 2014-02-28 18:49:45 |
| R15.htm | 20159 | 2014-02-28 18:49:45 |
| R16.htm | 5983 | 2014-02-28 18:49:45 |
| R17.htm | 10560 | 2014-02-28 18:49:45 |
| R18.htm | 55322 | 2014-02-28 18:49:45 |
| R19.htm | 316901 | 2014-02-28 18:49:45 |
| R2.htm | 100071 | 2014-02-28 18:49:45 |
| R20.htm | 184860 | 2014-02-28 18:49:45 |
| R21.htm | 246871 | 2014-02-28 18:49:45 |
| R22.htm | 90526 | 2014-02-28 18:49:45 |
| R23.htm | 119103 | 2014-02-28 18:49:45 |
| R24.htm | 160147 | 2014-02-28 18:49:45 |
| R25.htm | 19302 | 2014-02-28 18:49:45 |
| R26.htm | 53688 | 2014-02-28 18:49:45 |
| R27.htm | 110982 | 2014-02-28 18:49:45 |
| R28.htm | 30129 | 2014-02-28 18:49:45 |
| R29.htm | 11009 | 2014-02-28 18:49:45 |
| R3.htm | 15069 | 2014-02-28 18:49:45 |
| R30.htm | 34948 | 2014-02-28 18:49:45 |
| R31.htm | 27167 | 2014-02-28 18:49:45 |
| R32.htm | 13421 | 2014-02-28 18:49:45 |
| R33.htm | 5848 | 2014-02-28 18:49:45 |
| R34.htm | 20387 | 2014-02-28 18:49:45 |
| R35.htm | 9082 | 2014-02-28 18:49:45 |
| R36.htm | 48187 | 2014-02-28 18:49:45 |
| R37.htm | 23981 | 2014-02-28 18:49:45 |
| R38.htm | 17679 | 2014-02-28 18:49:45 |
| R39.htm | 39000 | 2014-02-28 18:49:45 |
| R4.htm | 67932 | 2014-02-28 18:49:45 |
| R40.htm | 94802 | 2014-02-28 18:49:45 |
| R41.htm | 136742 | 2014-02-28 18:49:45 |
| R42.htm | 37740 | 2014-02-28 18:49:45 |
| R43.htm | 57923 | 2014-02-28 18:49:45 |
| R44.htm | 50049 | 2014-02-28 18:49:45 |
| R45.htm | 56550 | 2014-02-28 18:49:45 |
| R46.htm | 69547 | 2014-02-28 18:49:45 |
| R47.htm | 38318 | 2014-02-28 18:49:45 |
| R48.htm | 9350 | 2014-02-28 18:49:45 |
| R49.htm | 21010 | 2014-02-28 18:49:45 |
| R5.htm | 16586 | 2014-02-28 18:49:45 |
| R50.htm | 11308 | 2014-02-28 18:49:45 |
| R51.htm | 33211 | 2014-02-28 18:49:45 |
| R52.htm | 67588 | 2014-02-28 18:49:45 |
| R53.htm | 46372 | 2014-02-28 18:49:45 |
| R54.htm | 6479 | 2014-02-28 18:49:45 |
| R55.htm | 14813 | 2014-02-28 18:49:45 |
| R56.htm | 742453 | 2014-02-28 18:49:45 |
| R57.htm | 13785 | 2014-02-28 18:49:45 |
| R58.htm | 10665 | 2014-02-28 18:49:45 |
| R59.htm | 19454 | 2014-02-28 18:49:45 |
| R6.htm | 53294 | 2014-02-28 18:49:45 |
| R7.htm | 148860 | 2014-02-28 18:49:45 |
| R8.htm | 245432 | 2014-02-28 18:49:45 |
| R9.htm | 8491 | 2014-02-28 18:49:45 |
| report.css | 2740 | 2014-02-28 18:49:45 |
| Show.js | 1410 | 2014-02-28 18:49:45 |