Parent Directory| Name | Size | Last Modified |
|---|---|---|
 0000874015-18-000047-index-headers.html | 2018-02-28 16:26:57 | |
| 0000874015-18-000047-index.html | 2018-02-28 16:26:57 | |
| 0000874015-18-000047.txt | 2018-02-28 16:26:57 | |
 0000874015-18-000047-xbrl.zip | 381383 | 2018-02-28 16:26:57 |
| exhibit10_10.htm | 1452545 | 2018-02-28 16:26:57 |
| exhibit10_17.htm | 978818 | 2018-02-28 16:26:57 |
| exhibit10_4.htm | 40493 | 2018-02-28 16:26:57 |
| exhibit14_1.htm | 58236 | 2018-02-28 16:26:57 |
| exhibit21_1.htm | 3367 | 2018-02-28 16:26:57 |
| exhibit23_1.htm | 4060 | 2018-02-28 16:26:57 |
| exhibit31_1.htm | 12274 | 2018-02-28 16:26:57 |
| exhibit31_2.htm | 12268 | 2018-02-28 16:26:57 |
| exhibit32_1.htm | 7095 | 2018-02-28 16:26:57 |
| exhibit3_1.htm | 94775 | 2018-02-28 16:26:57 |
| exhibit4_2.htm | 13835 | 2018-02-28 16:26:57 |
| FilingSummary.xml | 56271 | 2018-02-28 16:26:57 |
| Financial_Report.xlsx | 151249 | 2018-02-28 16:26:57 |
| form10k.htm | 2881366 | 2018-02-28 16:26:57 |
 image02.jpg | 112488 | 2018-02-28 16:26:57 |
 image10.jpg | 46106 | 2018-02-28 16:26:57 |
 image11.jpg | 17854 | 2018-02-28 16:26:57 |
 image12.jpg | 31669 | 2018-02-28 16:26:57 |
 image13.jpg | 25608 | 2018-02-28 16:26:57 |
 image14.jpg | 24762 | 2018-02-28 16:26:57 |
 image43.jpg | 32824 | 2018-02-28 16:26:57 |
 image44.jpg | 175516 | 2018-02-28 16:26:57 |
 image46.jpg | 36205 | 2018-02-28 16:26:57 |
 image47.jpg | 43354 | 2018-02-28 16:26:57 |
 image48.jpg | 54856 | 2018-02-28 16:26:57 |
 image50.jpg | 49775 | 2018-02-28 16:26:57 |
 image52.jpg | 60795 | 2018-02-28 16:26:57 |
 image53.jpg | 118421 | 2018-02-28 16:26:57 |
 image54.jpg | 10120 | 2018-02-28 16:26:57 |
 image55.jpg | 75998 | 2018-02-28 16:26:57 |
 image56.jpg | 62479 | 2018-02-28 16:26:57 |
| ions-20171231.xml | 3091078 | 2018-02-28 16:26:57 |
| ions-20171231.xsd | 113561 | 2018-02-28 16:26:57 |
| ions-20171231_cal.xml | 134941 | 2018-02-28 16:26:57 |
| ions-20171231_def.xml | 723904 | 2018-02-28 16:26:57 |
| ions-20171231_lab.xml | 1577441 | 2018-02-28 16:26:57 |
| ions-20171231_pre.xml | 988906 | 2018-02-28 16:26:57 |
| R1.htm | 28241 | 2018-02-28 16:26:57 |
| R10.htm | 228837 | 2018-02-28 16:26:57 |
| R11.htm | 131736 | 2018-02-28 16:26:57 |
| R12.htm | 65812 | 2018-02-28 16:26:57 |
| R13.htm | 94638 | 2018-02-28 16:26:57 |
| R14.htm | 149134 | 2018-02-28 16:26:57 |
| R15.htm | 93355 | 2018-02-28 16:26:57 |
| R16.htm | 106152 | 2018-02-28 16:26:57 |
| R17.htm | 5007 | 2018-02-28 16:26:57 |
| R18.htm | 8007 | 2018-02-28 16:26:57 |
| R19.htm | 148972 | 2018-02-28 16:26:57 |
| R2.htm | 79452 | 2018-02-28 16:26:57 |
| R20.htm | 264104 | 2018-02-28 16:26:57 |
| R21.htm | 152709 | 2018-02-28 16:26:57 |
| R22.htm | 132452 | 2018-02-28 16:26:57 |
| R23.htm | 63991 | 2018-02-28 16:26:57 |
| R24.htm | 85154 | 2018-02-28 16:26:57 |
| R25.htm | 150703 | 2018-02-28 16:26:57 |
| R26.htm | 106835 | 2018-02-28 16:26:57 |
| R27.htm | 148854 | 2018-02-28 16:26:57 |
| R28.htm | 6128 | 2018-02-28 16:26:57 |
| R29.htm | 85198 | 2018-02-28 16:26:57 |
| R3.htm | 17616 | 2018-02-28 16:26:57 |
| R30.htm | 84857 | 2018-02-28 16:26:57 |
| R31.htm | 33199 | 2018-02-28 16:26:57 |
| R32.htm | 11267 | 2018-02-28 16:26:57 |
| R33.htm | 19193 | 2018-02-28 16:26:57 |
| R34.htm | 6181 | 2018-02-28 16:26:57 |
| R35.htm | 7885 | 2018-02-28 16:26:57 |
| R36.htm | 37829 | 2018-02-28 16:26:57 |
| R37.htm | 4907 | 2018-02-28 16:26:57 |
| R38.htm | 5881 | 2018-02-28 16:26:57 |
| R39.htm | 25047 | 2018-02-28 16:26:57 |
| R4.htm | 62857 | 2018-02-28 16:26:57 |
| R40.htm | 8796 | 2018-02-28 16:26:57 |
| R41.htm | 8601 | 2018-02-28 16:26:57 |
| R42.htm | 58861 | 2018-02-28 16:26:57 |
| R43.htm | 18399 | 2018-02-28 16:26:57 |
| R44.htm | 7758 | 2018-02-28 16:26:57 |
| R45.htm | 30299 | 2018-02-28 16:26:57 |
| R46.htm | 24723 | 2018-02-28 16:26:57 |
| R47.htm | 73823 | 2018-02-28 16:26:57 |
| R48.htm | 36211 | 2018-02-28 16:26:57 |
| R49.htm | 18415 | 2018-02-28 16:26:57 |
| R5.htm | 22295 | 2018-02-28 16:26:57 |
| R50.htm | 66986 | 2018-02-28 16:26:57 |
| R51.htm | 25840 | 2018-02-28 16:26:57 |
| R52.htm | 19537 | 2018-02-28 16:26:57 |
| R53.htm | 27818 | 2018-02-28 16:26:57 |
| R54.htm | 28053 | 2018-02-28 16:26:57 |
| R55.htm | 31069 | 2018-02-28 16:26:57 |
| R56.htm | 71919 | 2018-02-28 16:26:57 |
| R57.htm | 55216 | 2018-02-28 16:26:57 |
| R58.htm | 32648 | 2018-02-28 16:26:57 |
| R59.htm | 12005 | 2018-02-28 16:26:57 |
| R6.htm | 70449 | 2018-02-28 16:26:57 |
| R60.htm | 20357 | 2018-02-28 16:26:57 |
| R61.htm | 9228 | 2018-02-28 16:26:57 |
| R62.htm | 24638 | 2018-02-28 16:26:57 |
| R63.htm | 72691 | 2018-02-28 16:26:57 |
| R64.htm | 34744 | 2018-02-28 16:26:57 |
| R65.htm | 25441 | 2018-02-28 16:26:57 |
| R66.htm | 15953 | 2018-02-28 16:26:57 |
| R67.htm | 70136 | 2018-02-28 16:26:57 |
| R68.htm | 100704 | 2018-02-28 16:26:57 |
| R69.htm | 39714 | 2018-02-28 16:26:57 |
| R7.htm | 9057 | 2018-02-28 16:26:57 |
| R70.htm | 36954 | 2018-02-28 16:26:57 |
| R71.htm | 40104 | 2018-02-28 16:26:57 |
| R72.htm | 82464 | 2018-02-28 16:26:57 |
| R73.htm | 45536 | 2018-02-28 16:26:57 |
| R74.htm | 20738 | 2018-02-28 16:26:57 |
| R75.htm | 35141 | 2018-02-28 16:26:57 |
| R76.htm | 15140 | 2018-02-28 16:26:57 |
| R77.htm | 21983 | 2018-02-28 16:26:57 |
| R78.htm | 20267 | 2018-02-28 16:26:57 |
| R79.htm | 16624 | 2018-02-28 16:26:57 |
| R8.htm | 119929 | 2018-02-28 16:26:57 |
| R80.htm | 30929 | 2018-02-28 16:26:57 |
| R81.htm | 5773 | 2018-02-28 16:26:57 |
| R82.htm | 32094 | 2018-02-28 16:26:57 |
| R83.htm | 11148 | 2018-02-28 16:26:57 |
| R84.htm | 62829 | 2018-02-28 16:26:57 |
| R85.htm | 25344 | 2018-02-28 16:26:57 |
| R86.htm | 8388 | 2018-02-28 16:26:57 |
| R87.htm | 10310 | 2018-02-28 16:26:57 |
| R88.htm | 108408 | 2018-02-28 16:26:57 |
| R9.htm | 8914 | 2018-02-28 16:26:57 |
| report.css | 2768 | 2018-02-28 16:26:57 |
| Show.js | 1411 | 2018-02-28 16:26:57 |