Document Format Files
| Seq | Description | Document | Type | Size |
|---|---|---|---|---|
| 1 | S-1 | d577473ds1.htm | S-1 | 3644482 |
| 2 | EX-3.1 | d577473dex31.htm | EX-3.1 | 232768 |
| 3 | EX-3.2 | d577473dex32.htm | EX-3.2 | 26515 |
| 4 | EX-3.3 | d577473dex33.htm | EX-3.3 | 68710 |
| 5 | EX-3.4 | d577473dex34.htm | EX-3.4 | 106595 |
| 6 | EX-4.1 | d577473dex41.htm | EX-4.1 | 10150 |
| 7 | EX-4.2 | d577473dex42.htm | EX-4.2 | 129806 |
| 8 | EX-10.1 | d577473dex101.htm | EX-10.1 | 271336 |
| 9 | EX-10.2 | d577473dex102.htm | EX-10.2 | 250641 |
| 10 | EX-10.3 | d577473dex103.htm | EX-10.3 | 65043 |
| 11 | EX-10.4 | d577473dex104.htm | EX-10.4 | 972733 |
| 12 | EX-10.5 | d577473dex105.htm | EX-10.5 | 1821532 |
| 13 | EX-10.6 | d577473dex106.htm | EX-10.6 | 346353 |
| 14 | EX-10.7 | d577473dex107.htm | EX-10.7 | 454427 |
| 15 | EX-10.8 | d577473dex108.htm | EX-10.8 | 189143 |
| 16 | EX-10.9 | d577473dex109.htm | EX-10.9 | 470271 |
| 17 | EX-10.10 | d577473dex1010.htm | EX-10.10 | 331559 |
| 18 | EX-10.11 | d577473dex1011.htm | EX-10.11 | 51922 |
| 19 | EX-10.12 | d577473dex1012.htm | EX-10.12 | 6681 |
| 20 | EX-10.13 | d577473dex1013.htm | EX-10.13 | 12342 |
| 21 | EX-10.14 | d577473dex1014.htm | EX-10.14 | 13987 |
| 22 | EX-10.15 | d577473dex1015.htm | EX-10.15 | 21759 |
| 23 | EX-10.16 | d577473dex1016.htm | EX-10.16 | 10365 |
| 24 | EX-10.17 | d577473dex1017.htm | EX-10.17 | 13934 |
| 25 | EX-10.18 | d577473dex1018.htm | EX-10.18 | 17162 |
| 26 | EX-10.19 | d577473dex1019.htm | EX-10.19 | 64587 |
| 27 | EX-10.20 | d577473dex1020.htm | EX-10.20 | 36182 |
| 28 | EX-21.1 | d577473dex211.htm | EX-21.1 | 2468 |
| 29 | EX-23.1 | d577473dex231.htm | EX-23.1 | 1315 |
| 30 | GRAPHIC | g577473dsp011.jpg | GRAPHIC | 423778 |
| 31 | GRAPHIC | g577473dsp012.jpg | GRAPHIC | 190658 |
| 32 | GRAPHIC | g577473dsp075.jpg | GRAPHIC | 4610 |
| 33 | GRAPHIC | g577473dsp154.jpg | GRAPHIC | 1068 |
| 34 | GRAPHIC | g577473dsp286.jpg | GRAPHIC | 144406 |
| 35 | GRAPHIC | g577473g00j93.jpg | GRAPHIC | 121845 |
| 36 | GRAPHIC | g577473g00n24.jpg | GRAPHIC | 206057 |
| 37 | GRAPHIC | g577473g00q62.jpg | GRAPHIC | 96684 |
| 38 | GRAPHIC | g577473g01r13.jpg | GRAPHIC | 94751 |
| 39 | GRAPHIC | g577473g01t35.jpg | GRAPHIC | 148348 |
| 40 | GRAPHIC | g577473g02s13.jpg | GRAPHIC | 87396 |
| 41 | GRAPHIC | g577473g06x78.jpg | GRAPHIC | 52862 |
| 42 | GRAPHIC | g577473g06y22.jpg | GRAPHIC | 57427 |
| 43 | GRAPHIC | g577473g0728114655375.jpg | GRAPHIC | 2397 |
| 44 | GRAPHIC | g577473g07h29.jpg | GRAPHIC | 102585 |
| 45 | GRAPHIC | g577473g07p17.jpg | GRAPHIC | 158600 |
| 46 | GRAPHIC | g577473g07v16.jpg | GRAPHIC | 42715 |
| 47 | GRAPHIC | g577473g0827192133182.jpg | GRAPHIC | 4478 |
| 48 | GRAPHIC | g577473g0827225606929.jpg | GRAPHIC | 3996 |
| 49 | GRAPHIC | g577473g08s31.jpg | GRAPHIC | 96839 |
| 50 | GRAPHIC | g577473g09j11.jpg | GRAPHIC | 63798 |
| 51 | GRAPHIC | g577473g09p51.jpg | GRAPHIC | 47295 |
| 52 | GRAPHIC | g577473g10r50.jpg | GRAPHIC | 60740 |
| 53 | GRAPHIC | g577473g11q70.jpg | GRAPHIC | 77016 |
| 54 | GRAPHIC | g577473g13a59.jpg | GRAPHIC | 63925 |
| 55 | GRAPHIC | g577473g13m88.jpg | GRAPHIC | 167789 |
| 56 | GRAPHIC | g577473g15t03.jpg | GRAPHIC | 41013 |
| 57 | GRAPHIC | g577473g16i18.jpg | GRAPHIC | 65631 |
| 58 | GRAPHIC | g577473g16w26.jpg | GRAPHIC | 48233 |
| 59 | GRAPHIC | g577473g18a17.jpg | GRAPHIC | 44713 |
| 60 | GRAPHIC | g577473g20f55.jpg | GRAPHIC | 176716 |
| 61 | GRAPHIC | g577473g22n74.jpg | GRAPHIC | 65970 |
| 62 | GRAPHIC | g577473g23g34.jpg | GRAPHIC | 80110 |
| 63 | GRAPHIC | g577473g23l75.jpg | GRAPHIC | 157214 |
| 64 | GRAPHIC | g577473g23z05.jpg | GRAPHIC | 47115 |
| 65 | GRAPHIC | g577473g24k54.jpg | GRAPHIC | 132536 |
| 66 | GRAPHIC | g577473g24z45.jpg | GRAPHIC | 111759 |
| 67 | GRAPHIC | g577473g26i42.jpg | GRAPHIC | 137883 |
| 68 | GRAPHIC | g577473g27r27.jpg | GRAPHIC | 47735 |
| 69 | GRAPHIC | g577473g27x58.jpg | GRAPHIC | 64649 |
| 70 | GRAPHIC | g577473g29u46.jpg | GRAPHIC | 46942 |
| 71 | GRAPHIC | g577473g30l44b.jpg | GRAPHIC | 57899 |
| 72 | GRAPHIC | g577473g31l57.jpg | GRAPHIC | 143885 |
| 73 | GRAPHIC | g577473g31q84.jpg | GRAPHIC | 148069 |
| 74 | GRAPHIC | g577473g31x65.jpg | GRAPHIC | 90389 |
| 75 | GRAPHIC | g577473g33n24.jpg | GRAPHIC | 62240 |
| 76 | GRAPHIC | g577473g34j53.jpg | GRAPHIC | 82907 |
| 77 | GRAPHIC | g577473g35a86.jpg | GRAPHIC | 44232 |
| 78 | GRAPHIC | g577473g36l63.jpg | GRAPHIC | 6024 |
| 79 | GRAPHIC | g577473g36o60.jpg | GRAPHIC | 30427 |
| 80 | GRAPHIC | g577473g39f51.jpg | GRAPHIC | 135269 |
| 81 | GRAPHIC | g577473g39g60.jpg | GRAPHIC | 157057 |
| 82 | GRAPHIC | g577473g39x23.jpg | GRAPHIC | 67183 |
| 83 | GRAPHIC | g577473g39z29.jpg | GRAPHIC | 97916 |
| 84 | GRAPHIC | g577473g40e87.jpg | GRAPHIC | 11940 |
| 85 | GRAPHIC | g577473g40x40.jpg | GRAPHIC | 132319 |
| 86 | GRAPHIC | g577473g41u19.jpg | GRAPHIC | 124498 |
| 87 | GRAPHIC | g577473g44g06.jpg | GRAPHIC | 45046 |
| 88 | GRAPHIC | g577473g45k25.jpg | GRAPHIC | 183042 |
| 89 | GRAPHIC | g577473g45n08.jpg | GRAPHIC | 75003 |
| 90 | GRAPHIC | g577473g46u21.jpg | GRAPHIC | 67251 |
| 91 | GRAPHIC | g577473g49b70.jpg | GRAPHIC | 110365 |
| 92 | GRAPHIC | g577473g49r61.jpg | GRAPHIC | 59029 |
| 93 | GRAPHIC | g577473g52h84.jpg | GRAPHIC | 54485 |
| 94 | GRAPHIC | g577473g54j05.jpg | GRAPHIC | 76798 |
| 95 | GRAPHIC | g577473g57b26.jpg | GRAPHIC | 144076 |
| 96 | GRAPHIC | g577473g58j08.jpg | GRAPHIC | 117502 |
| 97 | GRAPHIC | g577473g59j83.jpg | GRAPHIC | 32743 |
| 98 | GRAPHIC | g577473g60j60.jpg | GRAPHIC | 148409 |
| 99 | GRAPHIC | g577473g61i64.jpg | GRAPHIC | 43711 |
| 100 | GRAPHIC | g577473g61l35.jpg | GRAPHIC | 96630 |
| 101 | GRAPHIC | g577473g62j12.jpg | GRAPHIC | 59683 |
| 102 | GRAPHIC | g577473g63l96.jpg | GRAPHIC | 73630 |
| 103 | GRAPHIC | g577473g63y24.jpg | GRAPHIC | 56603 |
| 104 | GRAPHIC | g577473g64l56.jpg | GRAPHIC | 53591 |
| 105 | GRAPHIC | g577473g64o09.jpg | GRAPHIC | 155260 |
| 106 | GRAPHIC | g577473g64o36.jpg | GRAPHIC | 72509 |
| 107 | GRAPHIC | g577473g65q43.jpg | GRAPHIC | 86261 |
| 108 | GRAPHIC | g577473g65z32.jpg | GRAPHIC | 86917 |
| 109 | GRAPHIC | g577473g67c08.jpg | GRAPHIC | 46999 |
| 110 | GRAPHIC | g577473g67g21.jpg | GRAPHIC | 163569 |
| 111 | GRAPHIC | g577473g68w65.jpg | GRAPHIC | 101072 |
| 112 | GRAPHIC | g577473g69i22.jpg | GRAPHIC | 59959 |
| 113 | GRAPHIC | g577473g69m59.jpg | GRAPHIC | 172983 |
| 114 | GRAPHIC | g577473g69r82.jpg | GRAPHIC | 148415 |
| 115 | GRAPHIC | g577473g69u64.jpg | GRAPHIC | 201782 |
| 116 | GRAPHIC | g577473g70t46.jpg | GRAPHIC | 219189 |
| 117 | GRAPHIC | g577473g70y88.jpg | GRAPHIC | 13289 |
| 118 | GRAPHIC | g577473g71z26.jpg | GRAPHIC | 51948 |
| 119 | GRAPHIC | g577473g72u29.jpg | GRAPHIC | 157568 |
| 120 | GRAPHIC | g577473g73r80.jpg | GRAPHIC | 74152 |
| 121 | GRAPHIC | g577473g73u45.jpg | GRAPHIC | 48296 |
| 122 | GRAPHIC | g577473g75a56.jpg | GRAPHIC | 43554 |
| 123 | GRAPHIC | g577473g76c10.jpg | GRAPHIC | 60057 |
| 124 | GRAPHIC | g577473g76e32.jpg | GRAPHIC | 88789 |
| 125 | GRAPHIC | g577473g77g82.jpg | GRAPHIC | 43910 |
| 126 | GRAPHIC | g577473g77j75.jpg | GRAPHIC | 162837 |
| 127 | GRAPHIC | g577473g79h10.jpg | GRAPHIC | 123070 |
| 128 | GRAPHIC | g577473g79v93.jpg | GRAPHIC | 51893 |
| 129 | GRAPHIC | g577473g79y34.jpg | GRAPHIC | 44548 |
| 130 | GRAPHIC | g577473g81q48.jpg | GRAPHIC | 114370 |
| 131 | GRAPHIC | g577473g82i28.jpg | GRAPHIC | 58573 |
| 132 | GRAPHIC | g577473g82x02.jpg | GRAPHIC | 47076 |
| 133 | GRAPHIC | g577473g83f62.jpg | GRAPHIC | 161725 |
| 134 | GRAPHIC | g577473g84e19.jpg | GRAPHIC | 58630 |
| 135 | GRAPHIC | g577473g86q17.jpg | GRAPHIC | 62248 |
| 136 | GRAPHIC | g577473g86t89.jpg | GRAPHIC | 50680 |
| 137 | GRAPHIC | g577473g89m77.jpg | GRAPHIC | 53634 |
| 138 | GRAPHIC | g577473g89o79.jpg | GRAPHIC | 91012 |
| 139 | GRAPHIC | g577473g90f13.jpg | GRAPHIC | 76807 |
| 140 | GRAPHIC | g577473g91a29.jpg | GRAPHIC | 45643 |
| 141 | GRAPHIC | g577473g92d60.jpg | GRAPHIC | 73241 |
| 142 | GRAPHIC | g577473g92g89.jpg | GRAPHIC | 193909 |
| 143 | GRAPHIC | g577473g92s05.jpg | GRAPHIC | 160986 |
| 144 | GRAPHIC | g577473g94g64.jpg | GRAPHIC | 53940 |
| 145 | GRAPHIC | g577473g95w29.jpg | GRAPHIC | 41188 |
| 146 | GRAPHIC | g577473g96s44.jpg | GRAPHIC | 66472 |
| 147 | GRAPHIC | g577473g98u47.jpg | GRAPHIC | 52480 |
| 148 | GRAPHIC | g577473snap005.jpg | GRAPHIC | 7201 |
| Complete submission text file | 0001193125-18-323562.txt | 24291814 |
IRS No.: 813467528 | State of Incorp.: DE | Fiscal Year End: 1231
Type: S-1 | Act: 33 | File No.: 333-228300 | Film No.: 181172489
SIC: 2836 Biological Products, (No Diagnostic Substances)
Office of Life Sciences
