Form 10-K - Annual report [Section 13 and 15(d), not S-K Item 405]:
SEC Accession No. 0001636282-26-000020
Filing Date
2026-02-19
Accepted
2026-02-19 16:01:23
Documents
118
Period of Report
2025-12-31

Document Format Files

Seq Description Document Type Size
1 10-K syre-20251231.htm   iXBRL 10-K 2697670
2 EX-10.5 ex105formofrsuawardagreeme.htm EX-10.5 45461
3 EX-21.1 ex211-subsidiariesofspyret.htm EX-21.1 2243
4 EX-23.1 ex231kpmgconsentfye2025.htm EX-23.1 2298
5 EX-23.2 ex232pwcconsent10k.htm EX-23.2 2175
6 EX-31.1 spyre-20251231xex311.htm EX-31.1 9602
7 EX-31.2 spyre-20251231xex312.htm EX-31.2 9611
8 EX-32.1 spyre-20251231xex321.htm EX-32.1 7290
14 GRAPHIC syre-20251231_g1.jpg GRAPHIC 176591
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16 GRAPHIC syre-20251231_g2.jpg GRAPHIC 191682
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21 GRAPHIC syre-20251231_g7.jpg GRAPHIC 226170
22 GRAPHIC syre-20251231_g8.jpg GRAPHIC 343962
23 GRAPHIC syre-20251231_g9.jpg GRAPHIC 354608
  Complete submission text file 0001636282-26-000020.txt   17902651

Data Files

Seq Description Document Type Size
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12 XBRL TAXONOMY EXTENSION LABEL LINKBASE DOCUMENT syre-20251231_lab.xml EX-101.LAB 1032975
13 XBRL TAXONOMY EXTENSION PRESENTATION LINKBASE DOCUMENT syre-20251231_pre.xml EX-101.PRE 801460
121 EXTRACTED XBRL INSTANCE DOCUMENT syre-20251231_htm.xml XML 1685888
Mailing Address 221 CRESCENT STREET BUILDING 23, SUITE 105 WALTHAM MA 02453
Business Address 221 CRESCENT STREET BUILDING 23, SUITE 105 WALTHAM MA 02453 6176515940
Spyre Therapeutics, Inc. (Filer) CIK: 0001636282 (see all company filings)

EIN.: 464312787 | State of Incorp.: DE | Fiscal Year End: 1231
Type: 10-K | Act: 34 | File No.: 001-37722 | Film No.: 26654198
SIC: 2834 Pharmaceutical Preparations
(CF Office: 03 Life Sciences)