SECURITIES AND EXCHANGE COMMISSION Washington, D.C. Litigation Release No. 15905 / September 24, 1998 SECURITIES AND EXCHANGE COMMISSION v. RANGARAO PANGULURI, ET AL., Civil Action No. SACV 97-298 GLT (EEX) (C.D. Cal. April 9, 1997). The Securities and Exchange Commission today announced the entry of final judgments ("Final Judgments") in the second of two related "bad news" insider trading cases involving the securities of Alpha 1 Biomedicals, Inc. ("Alpha 1") and SciClone Pharmaceu- ticals, Inc. ("SciClone"). The Commission's Complaint alleged that, in April 1994, Rangarao Panguluri, then a Fellow at Wayne State University in Detroit, Michigan, tipped a group of doctors practicing in Anaheim, California about the negative results of clinical tests of a new drug developed by Alpha 1 and licensed to SciClone. Prior to the public announcement of the test results, the doctors traded in the securities of Alpha 1 and SciClone and, as a result, avoided losses and realized profits in the amount of $137,256. On September 17, 1998, Judge Gary L. Taylor of the United States District Court for the Central District of California entered Final Judgments against defendants Panguluri, Ravindra Alapati, Syam Gaddam, Gowtami Gaddam, and Ravi Makam. The Final Judgments to which Alapati, the Gaddams, and Makam consented, without admitting or denying the Complaint's allegations, enjoin them from further violations of Section 10(b) of the Securities Exchange Act of 1934 ("Exchange Act") and Rule 10b-5 thereunder, and order them to pay disgorgement of $61,000, $16,931, and $59,325, respectively, plus prejudgment interest thereon, and to pay civil penalties of $61,000, $16,931, and $59,325, respectively. In addition, the Final Judgment to which Panguluri consented, without admitting or denying the Complaint's allegations, enjoins him from further violations of antifraud provisions of the Exchange Act and orders him to pay a civil penalty of $75,000, an amount equal to the total avoided losses and realized profits of his direct tippees. The Complaint alleged that Thymosin alpha 1 ("Thymosin"), an experimental, anti-hepatitis drug, was Alpha 1's primary product- in-development during the relevant period and underwent a well- publicized, double-blinded, Phase III clinical trial at three medical research institutions. Successful performance by Thymosin in the Phase III clinical trial was a necessary step towards approval of the drug by the Food and Drug Administration. The Complaint also alleged that, on April 25, 1994, Dr. Panguluri and another doctor unblinded the study and learned that patients treated with Thymosin fared no better than patients given a placebo with respect to the study's most significant test parameter. The Complaint alleged that Panguluri tipped the negative results to his friends, Dr. Ravindra Alapati and Dr. Syam Gaddam, whose medical practice in California he was hoping to join upon completion of his fellowship. Panguluri's tip prompted Alapati and Gaddam to immediately sell all their Alpha 1 and/or SciClone securities, and Alapati to sell short 2,000 shares of Alpha 1 stock, on April 25 and 26, 1994. The Complaint further alleged that, after being tipped by Panguluri, Alapati, in turn, tipped his professional and social friend, Dr. Ravi Makam, and that Dr. and Mrs. Gaddam tipped Mrs. Gaddam's sister, who was not named as a defendant in the case. Prior to the opening of the market on April 28, 1994, Alpha 1 announced the negative news about the Thymosin clinical trial. The share price of both Alpha 1 and SciClone declined that day by approximately two-thirds. See Litigation Release 15322, dated April 10, 1997, for additional information.