Exhibit 5.3

        December 15, 2021 Mayer Brown LLP Two Palo Alto Square, Suite 300
3000 El Camino Real
Palo Alto, CA 94306-2112
United States of America   T: +1 650 331 2000 F: +1 650 331 2060   www.mayerbrown.com

TransCanada PipeLines Limited

450 - 1 Street S.W.

Calgary, Alberta, Canada, T2P 5H1

Ladies and Gentlemen:

We hereby consent to the references to this firm under the captions “Legal Matters” and “Documents Filed as Part of the Registration Statement” in the prospectus included as part of the registration statement on Form F-10 (Registration No. 333-261533) of TransCanada PipeLines Limited.

In giving this consent, we do not thereby admit that we are in the category of persons whose consent is required under Section 7 of the Securities Act of 1933, as amended.

Very truly yours,

/s/ Mayer Brown LLP

Mayer Brown LLP

Mayer Brown is a global services provider comprising an association of legal practices that are separate entities including
Mayer Brown LLP (Illinois, USA), Mayer Brown International LLP (England), Mayer Brown (a Hong Kong partnership)
and Tauil & Chequer Advogados (a Brazilian partnership).