X0306 4 2023-02-22 0000097745 THERMO FISHER SCIENTIFIC INC. TMO 0001216055 CASPER MARC N 168 THIRD AVENUE WALTHAM MA 02451 1 1 Chairman & CEO Common Stock 2023-02-22 4 A 0 4997 0 A 133701.53 D Common Stock 2023-02-22 4 A 0 16559 0 A 150260.53 D Common Stock 2023-02-23 4 F 0 3667 550.95 D 146593.53 D Common Stock 2023-02-23 4 F 0 2595 550.95 D 143998.53 D Common Stock 2000 I By Alison Casper 2020 Irrevocable Trust Common Stock 74155 I By Floral Park Associates, Inc. Common Stock 5000 I By MNC 2020 Irrevocable Trust Common Stock 3300 I By Spouse Stock Option (Right to Buy) 548.40 2023-02-22 4 A 0 33104 0 A 2031-02-22 Common Stock 33104 33104 D Shares represent a performance-based restricted stock unit award granted on February 23, 2022. The Company's Compensation Committee determined on February 22, 2023, that the performance criteria related to this award were satisfied. One-third of the shares vest on February 28, 2023 and 2024. The remaining one-third will vest on February 28, 2025, and is subject to adjustment (positive or negative) for long-term performance which is based on the comparison of the Company's total shareholder return compound annual growth rate ("CAGR") to the total shareholder return CAGR of each of the companies in the peer group, as specified within the award agreement, over the measurement period starting on January 1, 2022, through to December 31, 2024. The reporting person disclaims beneficial ownership of the securities reported herein as indirectly beneficially owned, except to the extent of any pecuniary interest therein. The option vests in four equal annual installments beginning on February 28, 2024. /s/ Melodie T. Morin, Attorney-in-Fact for Marc N. Casper 2023-02-24