X0306 4 2021-08-04 0000097745 THERMO FISHER SCIENTIFIC INC. TMO 0001216055 CASPER MARC N 168 THIRD AVENUE WALTHAM MA 02451 1 1 Chairman & CEO Common Stock 2021-08-04 4 S 0 800 536.49 D 208259.53 D Common Stock 2021-08-04 4 S 0 900 537.49 D 207359.53 D Common Stock 2021-08-04 4 S 0 3049 538.69 D 204310.53 D Common Stock 2021-08-04 4 S 0 3951 539.69 D 200359.53 D Common Stock 2021-08-04 4 S 0 1300 540.58 D 199059.53 D Common Stock 2021-08-05 4 S 0 794 537.64 D 198265.53 D Common Stock 2021-08-05 4 S 0 2491 538.78 D 195774.53 D Common Stock 2021-08-05 4 S 0 3120 539.64 D 192654.53 D Common Stock 2021-08-05 4 S 0 1584 540.69 D 191070.53 D Common Stock 2021-08-05 4 S 0 1543 541.96 D 189527.53 D Common Stock 2021-08-05 4 S 0 468 542.70 D 189059.53 D Common Stock 2000 I By Alison Casper 2020 Irrevocable Trust Common Stock 54330 I By Marc N. Casper 2012 Irrevocable Trust Common Stock 34825 I By Marc N. Casper 2020 Irrevocable Trust The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on November 16, 2020. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $535.80 to $536.78, inclusive. The reporting person undertakes to provide to Thermo Fisher Scientific Inc. ("TMO"), any security holder of TMO or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnotes (2), (3), (4), (5), (6), (7), (8), (9), (10), (11), and (12) to this Form 4. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $537.03 to $537.96 inclusive. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $538.17 to $539.14, inclusive. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $539.18 to $540.14, inclusive. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $540.26 to $540.90, inclusive. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $537.11 to $538.07, inclusive. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $538.18 to $539.16, inclusive. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $539.18 to $540.12, inclusive. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $540.32 to $541.27, inclusive. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $541.54 to $542.375, inclusive. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $542.57 to $542.98, inclusive. /s/ Melodie T. Morin, Attorney-in-Fact for Marc N. Casper 2021-08-06