X0306 4 2020-05-18 0000097745 THERMO FISHER SCIENTIFIC INC. TMO 0001387890 Stevenson Mark 168 THIRD AVENUE WALTHAM MA 02451 1 Executive Vice President & COO Common Stock 2020-05-18 4 M 0 25000 124.28 A 73621 D Common Stock 2020-05-18 4 S 0 2982 347.32 D 70639 D Common Stock 2020-05-18 4 S 0 9870 348.30 D 60769 D Common Stock 2020-05-18 4 S 0 8249 349.16 D 52520 D Common Stock 2020-05-18 4 S 0 3151 350.16 D 49369 D Common Stock 2020-05-18 4 S 0 748 351.03 D 48621 D Common Stock 477.42 I By 401(k) Common Stock 53959 I By Stevenson 2010 Living Trust Stock Option (Right to Buy) 124.28 2020-05-18 4 M 0 25000 0 D 2021-02-26 Common Stock 25000 25000 D The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on February 3, 2020. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $346.73 to $347.71, inclusive. The reporting person undertakes to provide to Thermo Fisher Scientific Inc. ("TMO"), any security holder of TMO or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnotes (2), (3), (4), (5) and (6) to this Form 4. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $347.76 to $348.75 inclusive. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $348.76 to $349.74, inclusive. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $349.76 to $350.73, inclusive. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $350.83 to $351.245, inclusive. Includes 83 shares acquired under the Issuer's employees' stock purchase plan on May 15, 2020. The option vested in four equal installments on February 26, 2015, 2016, 2017, and 2018. /s/ Melodie T. Morin, Attorney-in-Fact for Mark P. Stevenson 2020-05-20