SEC Form 3

FORM 3

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 INITIAL STATEMENT OF BENEFICIAL OWNERSHIP OF SECURITIES Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940

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1. Name and Address of Reporting Person* THERMO FISHER SCIENTIFIC INC. (Last) (First) (Middle) 168 THIRD AVENUE (Street) WALTHAM MA 02451 (City) (State) (Zip)	2. Date of Event Requiring Statement (Month/Day/Year) 12/08/2021	3. Issuer Name and Ticker or Trading Symbol Science 37 Holdings, Inc. [ SNCE ]
		4. Relationship of Reporting Person(s) to Issuer (Check all applicable) Director X 10% Owner Officer (give title below) Other (specify below)	5. If Amendment, Date of Original Filed (Month/Day/Year) 12/20/2021
			6. Individual or Joint/Group Filing (Check Applicable Line) Form filed by One Reporting Person X Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Beneficially Owned
1. Title of Security (Instr. 4)	2. Amount of Securities Beneficially Owned (Instr. 4)	3. Ownership Form: Direct (D) or Indirect (I) (Instr. 5)	4. Nature of Indirect Beneficial Ownership (Instr. 5)
Common Stock	17,379,797	I(1)(2)(3)	See footnote(1)(2)

Table II - Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 4)	2. Date Exercisable and Expiration Date (Month/Day/Year)		3. Title and Amount of Securities Underlying Derivative Security (Instr. 4)		4. Conversion or Exercise Price of Derivative Security	5. Ownership Form: Direct (D) or Indirect (I) (Instr. 5)	6. Nature of Indirect Beneficial Ownership (Instr. 5)
	Date Exercisable	Expiration Date	Title	Amount or Number of Shares

1. Name and Address of Reporting Person* THERMO FISHER SCIENTIFIC INC. (Last) (First) (Middle) 168 THIRD AVENUE (Street) WALTHAM MA 02451 (City) (State) (Zip) Relationship of Reporting Person(s) to Issuer Director X 10% Owner Officer (give title below) Other (specify below)

1. Name and Address of Reporting Person* Thermo Fisher Scientific Powder US Holdings Corp. (Last) (First) (Middle) 168 THIRD AVENUE (Street) WALTHAM MA 02451 (City) (State) (Zip) Relationship of Reporting Person(s) to Issuer Director X 10% Owner Officer (give title below) Other (specify below)

1. Name and Address of Reporting Person* Thermo Fisher Scientific Powder US Holdings Ltd (Last) (First) (Middle) 168 THIRD AVENUE (Street) WALTHAM MA 02451 (City) (State) (Zip) Relationship of Reporting Person(s) to Issuer Director X 10% Owner Officer (give title below) Other (specify below)

1. Name and Address of Reporting Person* Thermo Fisher Scientific Powder Holdings IV (Last) (First) (Middle) 168 THIRD AVENUE (Street) WALTHAM MA 02451 (City) (State) (Zip) Relationship of Reporting Person(s) to Issuer Director X 10% Owner Officer (give title below) Other (specify below)

1. Name and Address of Reporting Person* Thermo Fisher Scientific Powder Holdings III (Last) (First) (Middle) 168 THIRD AVENUE (Street) WALTHAM MA 02451 (City) (State) (Zip) Relationship of Reporting Person(s) to Issuer Director X 10% Owner Officer (give title below) Other (specify below)

1. Name and Address of Reporting Person* Thermo Fisher Scientific Powder Holdings II (Last) (First) (Middle) 168 THIRD AVENUE (Street) WALTHAM MA 02451 (City) (State) (Zip) Relationship of Reporting Person(s) to Issuer Director X 10% Owner Officer (give title below) Other (specify below)

1. Name and Address of Reporting Person* Thermo Fisher Scientific Powder Holdings I (Last) (First) (Middle) 168 THIRD AVENUE (Street) WALTHAM MA 02451 (City) (State) (Zip) Relationship of Reporting Person(s) to Issuer Director X 10% Owner Officer (give title below) Other (specify below)

1. Name and Address of Reporting Person* Spectra-Physics Holdings USA, LLC (Last) (First) (Middle) 168 THIRD AVENUE (Street) WALTHAM MA 02451 (City) (State) (Zip) Relationship of Reporting Person(s) to Issuer Director X 10% Owner Officer (give title below) Other (specify below)

1. Name and Address of Reporting Person* Fisher Scientific Worldwide Inc. (Last) (First) (Middle) 168 THIRD AVENUE (Street) WALTHAM MA 02451 (City) (State) (Zip) Relationship of Reporting Person(s) to Issuer Director X 10% Owner Officer (give title below) Other (specify below)

1. Name and Address of Reporting Person* Fisher Scientific International LLC (Last) (First) (Middle) 168 THIRD AVENUE (Street) WALTHAM MA 02451 (City) (State) (Zip) Relationship of Reporting Person(s) to Issuer Director X 10% Owner Officer (give title below) Other (specify below)

Explanation of Responses:

1. These shares of common stock, par value $0.0001 per share, of Science 37 Holdings, Inc. are held of record by Pharmaceutical Product Development, LLC ("Pharma LLC"). Wildcat Acquisition Holdings (UK) Limited ("Wildcat") is the sole member of Pharma LLC; Jaguar Holding Company II ("Jaguar II") is the sole shareholder of Wildcat; Jaguar Holding Company I, LLC ("Jaguar I") is the sole shareholder of Jaguar II; Eagle Holding Company II, LLC ("Eagle II") is the sole member of Jaguar I; PPD, Inc. ("PPD") is the sole member of Eagle II; Thermo Fisher Scientific Powder US Holdings Corp. ("Powder Holdings") is the sole shareholder of PPD; Thermo Fisher Scientific Powder US Holdings Ltd ("US Holdings") is the sole shareholder of Powder Holdings; Thermo Fisher Scientific Powder Holdings II Ltd ("Powder Holdings II") is the sole shareholder of US Holdings.

2. Thermo Fisher Scientific Powder Holdings IV Ltd ("Powder Holdings IV") and Thermo Fisher Scientific Powder Holdings I Ltd ("Powder Holdings I") are the 11.76% shareholder and the 88.24% shareholder, respectively, of Powder Holdings II; Thermo Fisher Scientific Powder Holdings III Ltd ("Powder Holdings III") is the sole shareholder of Powder Holdings IV; Spectra-Physics Holdings USA, LLC ("Spectra-Physics") is the sole shareholder of Powder Holdings I; Fisher Scientific Worldwide Inc. ("Worldwide") is the sole member of Spectra-Physics; Fisher Scientific International LLC ("Scientific International") is the sole shareholder of Worldwide; Scientific International is the sole shareholder of Powder Holdings III; and Thermo Fisher Scientific Inc. is the sole member of Scientific International. By virtue of such relationships, each of the reporting persons may be deemed to have beneficial ownership over such shares of common stock.

3. This report on Form 3 is jointly filed by the reporting persons. Each of the reporting persons disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Securities Exchange Act of 1934, as amended (the "Exchange Act"), except to the extent of its pecuniary interest therein. Disclosure of the information required by this Form was made by Pharma LLC, Wildcat, Jaguar II, Jaguar I, Eagle II and PPD pursuant to PPD, Inc.'s Form 3 filed on October 18, 2021 and Form 3/A filed on November 8, 2021.

Remarks:

This Form 3/A amends and restates the original Form 3 filed by the reporting persons on December 20, 2021, as amended by the reporting persons on December 27, 2021. This amendment is being filed to include Thermo Fisher Scientific Powder US Holdings Ltd, Thermo Fisher Scientific Powder Holdings I Ltd, Thermo Fisher Scientific Powder Holdings II Ltd, Thermo Fisher Scientific Powder Holdings III Ltd, Thermo Fisher Scientific Powder Holdings IV Ltd, Spectra-Physics Holdings USA LLC, Fisher Scientific Worldwide Inc. and Fisher Scientific International LLC as reporting persons.

	Thermo Fisher Scientific Inc., /s/ Michael Boxer, Senior Vice President and General Counsel	03/14/2024
	Thermo Fisher Scientific Powder US Holdings Corp., /s/ Anthony H. Smith, President	03/14/2024
	Thermo Fisher Scientific Powder US Holdings Ltd, /s/ Anthony H. Smith, Director	03/14/2024
	Thermo Fisher Scientific Powder Holdings IV Ltd, /s/ Anthony H. Smith, Director	03/14/2024
	Thermo Fisher Scientific Powder Holdings III Ltd, /s/ Anthony H. Smith, Director	03/14/2024
	Thermo Fisher Scientific Powder Holdings II Ltd, /s/ Anthony H. Smith, Director	03/14/2024
	Thermo Fisher Scientific Powder Holdings I Ltd, /s/ Anthony H. Smith, Director	03/14/2024
	Spectra-Physics Holdings USA, LLC, /s/ Anthony H. Smith, Treasurer and Assistant Secretary	03/14/2024
	Fisher Scientific Worldwide Inc., /s/ Anthony H. Smith, Treasurer and Assistant Secretary	03/14/2024
	Fisher Scientific International LLC, /s/ Anthony H. Smith, Vice President and Treasurer	03/14/2024
	** Signature of Reporting Person	Date
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