X0508 4 2026-03-03 0000097745 THERMO FISHER SCIENTIFIC INC. TMO 0001216055 CASPER MARC N 168 THIRD AVENUE WALTHAM MA 02451 1 1 Chairman & CEO 1 Common Stock 2026-03-03 4 M 0 5000 309.63 A 128925.358 D Common Stock 2026-03-03 4 S 0 360 495.29 D 128565.358 D Common Stock 2026-03-03 4 S 0 480 496.84 D 128085.358 D Common Stock 2026-03-03 4 S 0 680 498.14 D 127405.358 D Common Stock 2026-03-03 4 S 0 240 499.75 D 127165.358 D Common Stock 2026-03-03 4 S 0 382 500.55 D 126783.358 D Common Stock 2026-03-03 4 S 0 360 501.95 D 126423.358 D Common Stock 2026-03-03 4 S 0 120 502.59 D 126303.358 D Common Stock 2026-03-03 4 S 0 120 504.06 D 126183.358 D Common Stock 2026-03-03 4 S 0 448 506.74 D 125735.358 D Common Stock 2026-03-03 4 S 0 931 507.90 D 124804.358 D Common Stock 2026-03-03 4 S 0 759 508.95 D 124045.358 D Common Stock 2026-03-03 4 S 0 120 509.62 D 123925.358 D Common Stock 2026-03-04 4 M 0 5000 309.63 A 128925.358 D Common Stock 2026-03-04 4 S 0 447 509.89 D 128478.358 D Common Stock 2026-03-04 4 S 0 678 510.71 D 127800.358 D Common Stock 2026-03-04 4 S 0 1370 511.80 D 126430.358 D Common Stock 2026-03-04 4 S 0 1241 512.92 D 125189.358 D Common Stock 2026-03-04 4 S 0 815 513.63 D 124374.358 D Common Stock 2026-03-04 4 S 0 212 514.86 D 124162.358 D Common Stock 2026-03-04 4 S 0 119 515.77 D 124043.358 D Common Stock 2026-03-04 4 S 0 118 516.75 D 123925.358 D Common Stock 11300 I By Alison Casper 2020 Irrevocable Trust Common Stock 14608 I By Floral Park Associates, Inc. Common Stock 5000 I By MNC 2020 Irrevocable Trust Stock Option (Right to Buy) 309.63 2026-03-03 4 M 0 5000 0 D 2027-02-25 Common Stock 5000 49550 D Stock Option (Right to Buy) 309.63 2026-03-04 4 M 0 5000 0 D 2027-02-25 Common Stock 5000 44550 D The transactions reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on November 11, 2025. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $495.08 to $495.46, inclusive. The reporting person undertakes to provide to Thermo Fisher Scientific Inc. ("TMO"), any security holder of TMO or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnotes (2), (3), (4), (5), (6), (7), (8), (9), (10), (11), (12), (13), (14), (15), (16), (17), (18), (19), (20), and (21) to this Form 4. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $496.43 to $497.37, inclusive. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $497.80 to $498.70, inclusive. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $499.36 to $500.14, inclusive. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $500.47 to $501.44, inclusive. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $501.56 to $502.36, inclusive. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $502.59 to $502.60, inclusive. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $504.06 to $504.07, inclusive. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $506.40 to $507.38, inclusive. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $507.41 to $508.31, inclusive. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $508.57 to $509.28, inclusive. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $509.62 to $509.63, inclusive. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $509.283 to $510.22, inclusive. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $510.32 to $511.277, inclusive. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $511.323 to $512.303, inclusive. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $512.34 to $513.33, inclusive. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $513.341 to $514.328, inclusive. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $514.383 to $515.373, inclusive. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $515.378 to $516.065, inclusive. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $516.57 to $517.046, inclusive. The reporting person disclaims beneficial ownership of the securities reported herein as indirectly beneficially owned, except to the extent of any pecuniary interest therein. The reporting person disclaims beneficial ownership of the securities reported herein as indirectly beneficially owned, except to the extent of any pecuniary interest therein. The option vested in four equal installments on February 25, 2021, 2022, 2023, and 2024. /s/ Melodie T. Morin, Attorney-in-Fact for Marc N. Casper 2026-03-05