X0508 4 2025-11-13 0000097745 THERMO FISHER SCIENTIFIC INC. TMO 0001518973 Lagarde Michel 168 THIRD AVENUE WALTHAM MA 02451 1 Executive Vice President & COO 0 Common Stock 2025-11-13 4 M 0 4638 253.99 A 28117.909 D Common Stock 2025-11-13 4 S 0 4638 594.42 D 23479.909 D Stock Option (Right to Buy) 253.99 2025-11-13 4 M 0 4638 0 D 2026-02-26 Common Stock 4638 0 D The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $594.36 to $594.88, inclusive. The reporting person undertakes to provide to Thermo Fisher Scientific Inc. ("TMO"), any security holder of TMO or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote. The option vested in four equal installments on February 26, 2020, 2021, 2022, and 2023. /s/ Melodie T. Morin, Attorney-in-Fact for Michel Lagarde 2025-11-14