X0407 4 2023-04-28 0 0000949858 ACHIEVE LIFE SCIENCES, INC. ACHV 0001713369 Stewart Richard Alistair 22722 29TH DR SE SUITE 100 BOTHELL WA 98021 1 1 0 0 Executive Chairman 0 Common Stock 2023-04-28 4 M 0 5000 0.00 A 30751 D Common Stock 2023-04-28 4 F 0 2250 8.29 D 28501 D Common Stock 359 I By Spouse Common Stock 882 I By Ricanto Limited Performance Restricted Stock Unit (PRSU) 2023-04-28 4 M 0 5000 0.00 D 2025-01-26 Common Stock 5000 0 D Represents shares of common stock acquired upon settlement of the performance restricted stock units ("PRSUs") listed in Table II. Represents shares of common stock that have been withheld by the issuer to satisfy the tax liability in connection with the settlement of PRSUs. The reporting holder is a principal owner of Ricanto Limited. Each PRSU represents a contingent right to receive one share of the issuer's common stock at settlement. Pursuant to the terms of the PRSU 50% of the total shares underlying the PRSU vest on the achievement of a performance-based milestone, and 50% vest on the first anniversary of the achievement of such milestone. Sandra Thomson as attorney-in-fact for Richard Stewart 2023-05-01