X0306 4 2019-01-29 0 0000949858 ACHIEVE LIFE SCIENCES, INC. ACHV 0001713368 Clarke Anthony 520 PIKE STREET SUITE 2250 SEATTLE WA 98101 1 1 0 0 President & CSO Stock Option (right to buy) 1.42 2019-01-29 4 A 0 30000 0.00 A 2029-01-29 Common Stock 30000 30000 D Stock Option (right to buy) 1.42 2019-01-29 4 A 0 10000 0.00 A 2029-01-29 Common Stock 10000 10000 D The options vest 25% on the first anniversary of January 29, 2019 and thereafter in monthly installments over 36 months. Pursuant to the terms of the options 25% of the total shares underlying the option vest on the achievement of a performance-based milestone, and 75% vest in monthly installments over 24 months commencing one month from achievement of such milestone. The options will lapse in full if achievement of such milestone is not met by mid-2019 Sandra Thomson as attorney-in-fact for Anthony Clarke 2019-01-31