Collaboration and Other Agreements - Janssen Collaboration Cost Sharing (Details) (USD $)	3 Months Ended
	Mar. 31, 2015	Mar. 31, 2014	Dec. 31, 2014
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Research and Development Expense	$ 49,377,000	$ 35,292,000
Selling, general and administrative	49,505,000	34,715,000
Receivable from collaboration partners	24,025,000		26,970,000
Payable to collaboration partner	77,460,000		79,799,000
Janssen [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Payable to collaboration partner	77,500,000		79,800,000
Accrual for Taxes Other than Income Taxes			300,000
Collaboration and License Agreement with Janssen Biotech Inc [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Research and Development Expense	27,332,000	24,402,000
Selling, general and administrative	15,083,000	18,165,000
Receivable from collaboration partners	24,000,000		27,000,000
Collaboration and License Agreement with Janssen Biotech Inc [Member] | Receivable and Product Sales, Milestone Payment One [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Receivable from collaboration partners			20,000,000
Collaboration and License Agreement with Janssen Biotech Inc [Member] | Receivable and Product Sales, Milestone Payment Two [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Receivable from collaboration partners			3,900,000
Collaboration and License Agreement with Janssen Biotech Inc [Member] | Value Added Tax [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Receivable from collaboration partners			1,700,000
Counterparty's Share of Pre-tax Commercial Profits [Member] | Janssen [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Payable to collaboration partner			76,700,000
Cost-sharing Under the Agreement [Member] | Janssen [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Payable to collaboration partner			2,800,000
Collaboration Expense, Unadjusted [Member] | Collaboration and License Agreement with Janssen Biotech Inc [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Research and Development Expense	37,590,000	32,365,000
Selling, general and administrative	20,730,000	18,220,000
Increase (Decrease) for Cost Sharing [Member] | Collaboration and License Agreement with Janssen Biotech Inc [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Research and Development Expense	(10,258,000)	(7,963,000)
Selling, general and administrative	$ (5,647,000)	$ (55,000)