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Product Revenue, Net - Summary of Provisions and Credit Payments (Details) (USD $)
In Thousands, unless otherwise specified
3 Months Ended
Mar. 31, 2015
Mar. 31, 2014
Activity of Sales Related Deductions [Roll Forward]    
Beginning Balance $ 26,735us-gaap_ValuationAllowancesAndReservesBalance $ 1,206us-gaap_ValuationAllowancesAndReservesBalance
Provision related to current period product revenue 28,779us-gaap_ValuationAllowancesAndReservesChargedToOtherAccounts 8,639us-gaap_ValuationAllowancesAndReservesChargedToOtherAccounts
Credits/payments (20,972)us-gaap_ValuationAllowancesAndReservesDeductions (2,095)us-gaap_ValuationAllowancesAndReservesDeductions
Ending Balance $ 34,542us-gaap_ValuationAllowancesAndReservesBalance $ 7,750us-gaap_ValuationAllowancesAndReservesBalance