Share-based Compensation (Tables)

3 Months Ended

Mar. 31, 2013

Share-based Compensation

Schedule of Share-Based Compensation Expense by Award Type

	Three Months Ended
	March 31,
(in thousands)	2013		2012
Stock options	$	4,520	$	3,882
Performance shares	1,195		790
Restricted shares	231		181
Employee Stock Purchase Plan	46		51
Total	$	5,992	$	4,904

Schedule of Share-Based Compensation Expense by Financial Statement Location

	Three Months Ended
	March 31,
(in thousands)	2013		2012
Research and development	$	1,278	$	1,083
Selling, general and administrative	4,714		3,821
Total	$	5,992	$	4,904

Schedule Of Information About Equity Plans

	1995 Plan	2001 Plan	2005 Plan	Combined
Shares authorized for issuance	4,500,000	500,000	15,350,000	20,350,000
Shares outstanding	4,500,000	500,000	11,952,125	16,952,125
Shares available for grant	—	—	3,397,875	3,397,875

Schedule Of Weighted Average Fair Value Assumptions Using Black-Scholes Option-Pricing Model

Expected dividend yield			—
Range of risk free interest rate	1.15	%	—		1.36	%
Weighted-average volatility			57.99	%
Range of volatility	57.95	%	—		58.06	%
Range of expected option life (in years)	5.50		—		6.25

Schedule of Stock Options Outstanding and Exercisable

	Number of options	Weighted average exercise price		Weighted average remaining contractual term (years)	Aggregate intrinsic value (in thousands)
Outstanding	9,687,716	$	16.20	6.89	$	90,276
Exercisable	5,298,336	$	12.92	5.41	$	66,118

Schedule of Stock Option Activity - Current

	Shares Under Option		Weighted Average Exercise Price
Balance at December 31, 2012	8,814,831		$	15.26
Granted	1,066,548		$	23.68
Exercised	(119,390	)	$	10.94
Forfeited and cancelled	(74,273	)	$	19.97
Balance at March 31, 2013	9,687,716		$	16.20

Schedule Of Fair Value Of PSUs Assumptions Using Monte Carlo Simulation

	Three Months Ended
	March 31,
(in thousands)	2013			2012
Closing stock price on grant date	$	23.37		$	28.16
Performance period starting price	$	23.83		$	24.94
Term of award (in years)	2.99			2.99
Volatility	43.13		%	65.06		%
Risk-free interest rate	0.43		%	0.45		%
Expected dividend yield	0.00		%	0.00		%
Fair value per TSR PSU	$	32.63		$	45.37

Schedule of Performance Share Units Activity

	Share Units (in thousands)		Weighted- average grant date fair value
Balance at December 31, 2012	350,739		$	24.86
Granted	281,030		$	24.30
Exercised	—		$	—
Forfeited	(8,930	)	$	24.66
Vested	—		$	—
Balance at March 31, 2013	622,839		$	24.61

Schedule of Restricted Stock Awards Activity

	Share Units (in thousands)		Weighted- average grant date fair value
Balance at December 31, 2012	37,750		$	31.12
Granted	31,500		$	25.25
Vested	(33,583	)	$	31.51
Balance at March 31, 2013	35,667		$	25.57