SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549

                                  FORM 12B-25

                                                 Commission File Number  0-26476

                          NOTIFICATION OF LATE FILING


                                                                  
(Check One):      [  ] Form 10-K      [  ] Form 11-K      [  ] Form 20-F      [X] Form 10-Q
[  ] Form N-SAR


For Period Ended:    March 31, 2001
                     ---------------
[  ] Transition Report on Form 10-K        [  ] Transition Report on Form 10-Q
[  ] Transition Report on Form 20-F        [  ] Transition Report on Form N-SAR
[  ] Transition Report on Form 11-K

For the Transition Period Ended  N/A
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     Read attached instruction sheet before preparing form.  Please print or
type.

     Nothing in this form shall be construed to imply that the Commission has
verified any information contained herein.

     If the notification relates to a portion of the filing checked above,
identify item(s) to which the notification relates:  N/A
                                                    -----
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                        PART I.  REGISTRANT INFORMATION

Full name of registrant    SAFESCIENCE, INC.
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Former name if applicable

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Address of principal executive office (Street and number)

  Park Square Building, 31 St. James Avenue, 8th Floor,
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City, State and Zip Code   Boston, Massachusetts 02116
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                        PART II. RULE 12B-25(b) AND (c)

     If the subject report could not be filed without unreasonable effort or
expense and the registrant seeks relief pursuant to Rule 12b-25(b), the
following should be completed.  (Check appropriate box.)

[ X ]  (a) The reasons described in reasonable detail in Part III of this form
       could not be eliminated without unreasonable effort or expense;

[ X ]  (b) The subject annual report, semi-annual report, transition report on
       Form 10-K, 20-F, 11-K or Form N-SAR, or portion thereof will be filed on
       or before 15th calendar day following the prescribed due date; or the
       subject quarterly report or transition report on Form 10-Q, or portion
       thereof will be filed on or before the fifth calendar day following the
       prescribed due date; and


[   ]  (c) The accountant's statement or other exhibit required by Rule 12b-
       25(c) has been attached if applicable.

                              PART III.  NARRATIVE

     State below in reasonable detail the reasons why Form 10-K, 11-K, 20-F, 10-
Q, N-SAR or the transition report portion thereof could not be filed within the
prescribed time period.  (Attach extra sheets if needed).

          The Registrant is unable to complete its financial statements within
     the prescribed time period.

                          PART IV.  OTHER INFORMATION

     (1) Name and telephone number of person to contact in regard to this
notification.

Bradley J. Carver                               (617) 422-0674
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      (Name)                            (Area Code)  (Telephone Number)

     (2) Have all other periodic reports required under Sections 13 and 15(d) of
the Securities Exchange Act of 1934 or Section 30 of the Investment Company Act
of 1940 during the preceding 12 months or for such shorter period that the
registrant was required to file such report(s) been filed?  If the answer is no,
identify report(s).
                                                  [ X ] Yes  [   ] No

     (3) Is it anticipated that any significant change in results of operations
from the corresponding period for the last fiscal year will be reflected by the
earnings statements to be included in the subject report or portion thereof?
                                                  [  ] Yes  [ X ] No

     If so attach an explanation of the anticipated change, both narratively and
quantitatively, and, if appropriate, state the reasons why a reasonable estimate
of the results cannot be made.


Safescience, Inc. has caused this notification to be signed on its behalf by the
undersigned thereunto duly authorized.

Date: May 16, 2001              By: /s/ Bradley J. Carver
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                                    Name: Bradley J. Carver
                                    Title: Chief Executive Officer and President

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