-----BEGIN PRIVACY-ENHANCED MESSAGE-----
Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
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 TWSM7vrzLADbmYQaionwg5sDW3P6oaM5D3tdezXMm7z1T+B+twIDAQAB
MIC-Info: RSA-MD5,RSA,
 PjjTiCyZM3FaZ6J0mObYeZawXOtgCnK6jrWs4UmVepE6menOnGVSykooHj+IJ139
 Qlp0Qeh+LurmOn+91EPuXw==

<SEC-DOCUMENT>0001144204-10-015707.txt : 20100325
<SEC-HEADER>0001144204-10-015707.hdr.sgml : 20100325
<ACCEPTANCE-DATETIME>20100325185014
ACCESSION NUMBER:		0001144204-10-015707
CONFORMED SUBMISSION TYPE:	4
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20100322
FILED AS OF DATE:		20100325
DATE AS OF CHANGE:		20100325

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			TAKE TWO INTERACTIVE SOFTWARE INC
		CENTRAL INDEX KEY:			0000946581
		STANDARD INDUSTRIAL CLASSIFICATION:	SERVICES-PREPACKAGED SOFTWARE [7372]
		IRS NUMBER:				510350842
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1031

	BUSINESS ADDRESS:	
		STREET 1:		622 BROADWAY
		CITY:			NEW YORK
		STATE:			NY
		ZIP:			10012
		BUSINESS PHONE:		646 536 2842

	MAIL ADDRESS:	
		STREET 1:		622 BROADWAY
		CITY:			NEW YORK
		STATE:			NY
		ZIP:			10012

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			ICAHN ENTERPRISES HOLDINGS L.P.
		CENTRAL INDEX KEY:			0001034563
		STANDARD INDUSTRIAL CLASSIFICATION:	OPERATORS OF NONRESIDENTIAL BUILDINGS [6512]
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-34003
		FILM NUMBER:		10705576

	BUSINESS ADDRESS:	
		STREET 1:		445 HAMILTON AVENUE
		STREET 2:		SUITE 1210
		CITY:			WHITE PLAINS
		STATE:			NY
		ZIP:			10601
		BUSINESS PHONE:		914-614-7000

	MAIL ADDRESS:	
		STREET 1:		445 HAMILTON AVENUE
		STREET 2:		SUITE 1210
		CITY:			WHITE PLAINS
		STATE:			NY
		ZIP:			10601

	FORMER NAME:	
		FORMER CONFORMED NAME:	AMERICAN REAL ESTATE HOLDINGS L P
		DATE OF NAME CHANGE:	19980311

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			ICAHN OFFSHORE LP
		CENTRAL INDEX KEY:			0001322825
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-34003
		FILM NUMBER:		10705578

	BUSINESS ADDRESS:	
		STREET 1:		445 HAMILTON AVENUE
		STREET 2:		SUITE 1210
		CITY:			WHITE PLAINS
		STATE:			NY
		ZIP:			10601
		BUSINESS PHONE:		914-614-7000

	MAIL ADDRESS:	
		STREET 1:		445 HAMILTON AVENUE
		STREET 2:		SUITE 1210
		CITY:			WHITE PLAINS
		STATE:			NY
		ZIP:			10601

	FORMER NAME:	
		FORMER CONFORMED NAME:	Icahn Offshore LP
		DATE OF NAME CHANGE:	20050405

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			ICAHN ONSHORE LP
		CENTRAL INDEX KEY:			0001322826
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-34003
		FILM NUMBER:		10705577

	BUSINESS ADDRESS:	
		STREET 1:		445 HAMILTON AVENUE
		STREET 2:		SUITE 1210
		CITY:			WHITE PLAINS
		STATE:			NY
		ZIP:			10601
		BUSINESS PHONE:		914-614-7000

	MAIL ADDRESS:	
		STREET 1:		445 HAMILTON AVENUE
		STREET 2:		SUITE 1210
		CITY:			WHITE PLAINS
		STATE:			NY
		ZIP:			10601

	FORMER NAME:	
		FORMER CONFORMED NAME:	Icahn Onshore LP
		DATE OF NAME CHANGE:	20050405

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			IPH GP LLC
		CENTRAL INDEX KEY:			0001412091

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-34003
		FILM NUMBER:		10705580

	BUSINESS ADDRESS:	
		STREET 1:		445 HAMILTON AVENUE
		STREET 2:		SUITE 1210
		CITY:			WHITE PLAINS
		STATE:			NY
		ZIP:			10601
		BUSINESS PHONE:		914-614-7000

	MAIL ADDRESS:	
		STREET 1:		445 HAMILTON AVENUE
		STREET 2:		SUITE 1210
		CITY:			WHITE PLAINS
		STATE:			NY
		ZIP:			10601

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			ICAHN CAPITAL LP
		CENTRAL INDEX KEY:			0001412093

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-34003
		FILM NUMBER:		10705579

	BUSINESS ADDRESS:	
		STREET 1:		445 HAMILTON AVENUE
		STREET 2:		SUITE 1210
		CITY:			WHITE PLAINS
		STATE:			NY
		ZIP:			10601
		BUSINESS PHONE:		914-614-7000

	MAIL ADDRESS:	
		STREET 1:		445 HAMILTON AVENUE
		STREET 2:		SUITE 1210
		CITY:			WHITE PLAINS
		STATE:			NY
		ZIP:			10601

	FORMER NAME:	
		FORMER CONFORMED NAME:	ICAHN PARTNERS HOLDING LP
		DATE OF NAME CHANGE:	20070911
</SEC-HEADER>
<DOCUMENT>
<TYPE>4
<SEQUENCE>1
<FILENAME>v178655_ex.xml
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0303</schemaVersion>

    <documentType>4</documentType>

    <periodOfReport>2010-03-22</periodOfReport>

    <notSubjectToSection16>0</notSubjectToSection16>

    <issuer>
        <issuerCik>0000946581</issuerCik>
        <issuerName>TAKE TWO INTERACTIVE SOFTWARE INC</issuerName>
        <issuerTradingSymbol>TTWO</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001034563</rptOwnerCik>
            <rptOwnerName>ICAHN ENTERPRISES HOLDINGS L.P.</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>445 HAMILTON AVENUE</rptOwnerStreet1>
            <rptOwnerStreet2>SUITE 1210</rptOwnerStreet2>
            <rptOwnerCity>WHITE PLAINS</rptOwnerCity>
            <rptOwnerState>NY</rptOwnerState>
            <rptOwnerZipCode>10601</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001412091</rptOwnerCik>
            <rptOwnerName>IPH GP LLC</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>445 HAMILTON AVENUE</rptOwnerStreet1>
            <rptOwnerStreet2>SUITE 1210</rptOwnerStreet2>
            <rptOwnerCity>WHITE PLAINS</rptOwnerCity>
            <rptOwnerState>NY</rptOwnerState>
            <rptOwnerZipCode>10601</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001412093</rptOwnerCik>
            <rptOwnerName>ICAHN CAPITAL LP</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>445 HAMILTON AVENUE</rptOwnerStreet1>
            <rptOwnerStreet2>SUITE 1210</rptOwnerStreet2>
            <rptOwnerCity>WHITE PLAINS</rptOwnerCity>
            <rptOwnerState>NY</rptOwnerState>
            <rptOwnerZipCode>10601</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001322825</rptOwnerCik>
            <rptOwnerName>ICAHN OFFSHORE LP</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>445 HAMILTON AVENUE</rptOwnerStreet1>
            <rptOwnerStreet2>SUITE 1210</rptOwnerStreet2>
            <rptOwnerCity>WHITE PLAINS</rptOwnerCity>
            <rptOwnerState>NY</rptOwnerState>
            <rptOwnerZipCode>10601</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001322826</rptOwnerCik>
            <rptOwnerName>ICAHN ONSHORE LP</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>445 HAMILTON AVENUE</rptOwnerStreet1>
            <rptOwnerStreet2>SUITE 1210</rptOwnerStreet2>
            <rptOwnerCity>WHITE PLAINS</rptOwnerCity>
            <rptOwnerState>NY</rptOwnerState>
            <rptOwnerZipCode>10601</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable>
        <nonDerivativeTransaction>
            <securityTitle>
                <value>Common Stock, par value $0.01 per share (&quot;Shares&quot;)</value>
            </securityTitle>
            <transactionDate>
                <value>2010-03-22</value>
            </transactionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>P</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionAmounts>
                <transactionShares>
                    <value>36653</value>
                </transactionShares>
                <transactionPricePerShare>
                    <value>9.96</value>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>A</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>11620526</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>See FNS</value>
                    <footnoteId id="F1"/>
                    <footnoteId id="F2"/>
                    <footnoteId id="F3"/>
                    <footnoteId id="F4"/>
                    <footnoteId id="F5"/>
                    <footnoteId id="F6"/>
                </natureOfOwnership>
            </ownershipNature>
        </nonDerivativeTransaction>
    </nonDerivativeTable>

    <footnotes>
        <footnote id="F1">High River Limited Partnership (&quot;High River&quot;) directly beneficially owns 2,324,104 Shares, Icahn Partners LP (&quot;Icahn
 Partners&quot;) directly beneficially owns 3,436,075 Shares, Icahn Partners Master Fund LP (&quot;Icahn Master&quot;) directly beneficially
 owns 3,866,980 Shares, Icahn Partners Master Fund II LP (&quot;Icahn Master II&quot;) directly beneficially owns 1,446,200 Shares, and
 Icahn Partners Master Fund III LP (&quot;Icahn Master III&quot;) directly beneficially owns 547,167 Shares.</footnote>
        <footnote id="F2">Barberry Corp. (&quot;Barberry&quot;), is the sole member of Hopper Investments LLC (&quot;Hopper&quot;), which is the general partner of High
 River. Beckton Corp. (&quot;Beckton&quot;) is the sole stockholder of Icahn Enterprises G.P. Inc. (&quot;Icahn Enterprises GP&quot;), which is
 the general partner of Icahn Enterprises Holdings L.P. (&quot;Icahn Enterprises Holdings&quot;). Icahn Enterprises Holdings is the
 sole member of IPH GP LLC (&quot;IPH&quot;), which is the general partner of Icahn Capital LP (&quot;Icahn Capital&quot;). Icahn Capital is the
 general partner of each of Icahn Onshore LP (&quot;Icahn Onshore&quot;) and Icahn Offshore LP (&quot;Icahn Offshore&quot;). Icahn Onshore is the
 general partner of Icahn Partners. Icahn Offshore is the general partner of each of Icahn Master, Icahn Master II and Icahn
 Master III.</footnote>
        <footnote id="F3">Each of Barberry and Beckton is 100 percent owned by Carl C. Icahn. As such, Mr. Icahn is in a position indirectly to
 determine the investment and voting decisions made by each of High River, Icahn Partners, Icahn Master, Icahn Master II and
 Icahn Master III. Each of Hopper, Barberry and Mr. Icahn may be deemed to indirectly beneficially own (as that term is
 defined in Rule 13d-3 under the Act) the Shares which High River owns. Each of Hopper, Barberry and Mr. Icahn disclaims
 beneficial ownership of such Shares except to the extent of their pecuniary interest therein.</footnote>
        <footnote id="F4">Each of Icahn Onshore, Icahn Capital, IPH, Icahn Enterprises Holdings, Icahn Enterprises GP, Beckton and Mr. Icahn may be
 deemed to indirectly beneficially own (as that term is defined in Rule 13d-3 under the Act) the Shares which Icahn Partners
 owns. Each of Icahn Onshore, Icahn Capital, IPH, Icahn Enterprises Holdings, Icahn Enterprises GP, Beckton and Mr. Icahn
 disclaims beneficial ownership of such Shares except to the extent of their pecuniary interest therein.</footnote>
        <footnote id="F5">Each of Icahn Offshore, Icahn Capital, IPH, Icahn Enterprises Holdings, Icahn Enterprises GP, Beckton and Mr. Icahn may be
 deemed to indirectly beneficially own (as that term is defined in Rule 13d-3 under the Act) the Shares which each of Icahn
 Master, Icahn Master II and Icahn Master III owns. Each of Icahn Offshore, Icahn Capital, IPH, Icahn Enterprises Holdings,
 Icahn Enterprises GP, Beckton and Mr. Icahn disclaims beneficial ownership of such Shares except to the extent of their
 pecuniary interest therein.</footnote>
        <footnote id="F6">Please reference the Form 4 filing dated March 25, 2010, filed separately by certain other related Reporting Persons.</footnote>
    </footnotes>

    <ownerSignature>
        <signatureName>/s/ Icahn Enterprises Holdings L.P.</signatureName>
        <signatureDate>2010-03-25</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>/s/ IPH GP LLC</signatureName>
        <signatureDate>2010-03-25</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>/s/ Icahn Capital LP</signatureName>
        <signatureDate>2010-03-25</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>/s/ Icahn Offshore LP</signatureName>
        <signatureDate>2010-03-25</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>/s/ Icahn Onshore LP</signatureName>
        <signatureDate>2010-03-25</signatureDate>
    </ownerSignature>
</ownershipDocument>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
-----END PRIVACY-ENHANCED MESSAGE-----