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Note 12 - Restructured Debt Liability (Details Textual) - USD ($) $ / shares in Units, $ in Thousands				3 Months Ended
	Jan. 24, 2025	Jan. 24, 2024	Oct. 27, 2017	Mar. 31, 2025	Mar. 31, 2024	Dec. 31, 2024
Common Stock, Par or Stated Value Per Share (in dollars per share)				$ 0.001		$ 0.001
Gain (Loss) on Extinguishment of Debt				$ (22)	$ 14,520
Exchange and Termination Agreement with Deerfield Management Company, L.P. [Member]
Termination Agreement, Payable		$ 200
Payments for Exchange and Termination Agreement	$ 100	$ 100
Stock Issued During Period, Shares, New Issues (in shares)		676
Common Stock, Par or Stated Value Per Share (in dollars per share)		$ 0.001
Deerfield Loan [Member] \| Exchange and Termination Agreement [Member] \| Deerfield Management, L.P. [Member]
Extinguishment of Debt, Amount			$ 25,000
Repayments of Long-term Debt, Total			$ 2,500
Stock Issued During Period, Shares, Cancellation of Debt and Warrant Obligations, Percentage of Fully-diluted Shares Outstanding			2.00%
Liability for Contingent Milestone Payment, Noncurrent			$ 15,000	15,000		$ 15,000
Gain (Loss) on Extinguishment of Debt				14,500
Deerfield Loan [Member] \| Exchange and Termination Agreement [Member] \| Deerfield Management, L.P. [Member] \| Common Stock [Member]
Liability for Contingent Milestone Payment, Noncurrent				300
Deerfield Loan [Member] \| Exchange and Termination Agreement [Member] \| Deerfield Management, L.P. [Member] \| Cash [Member]
Liability for Contingent Milestone Payment, Noncurrent				$ 200