X0508 4 2023-08-23 0000946486 WINDTREE THERAPEUTICS INC /DE/ WINT 0001624401 Simonson Steven 2600 KELLY ROAD SUITE 100 WARRINGTON PA 18976 1 SVP, Chief Medical Officer 0 Common Stock 2023-08-23 4 A 0 15867 0 A 17440 D Common Stock 6 I By Trust Employee Stock Option (Right to Buy) 1.21 2023-08-23 4 A 0 23800 0 A 2033-08-23 Common Stock 23800 23800 D These shares represent restricted stock units (RSUs), which represent a contingent right to receive the equivalent number of shares of common stock. These RSUs shall vest with respect to one-third of the total number of shares subject to the RSUs on an annual basis (every 12 months) with the first vest date on August 23, 2024 provided that the reporting person remains in continuous service on each vesting date. Holding amount represents issuer's matching stock contribution pursuant to 401(k) plan. This employee stock option shall vest and become exercisable with respect to one-third of the total number of shares subject to the option on an annual basis (every 12 months) with the first vest date on August 23, 2024 provided that the reporting person remains in continuous service on each vesting date. /s/ Jamie McAndrew, as Attorney-in-Fact 2023-08-25