Note 6 - Property and Equipment - Property and Equipment (Details) - USD ($) $ in Thousands	Dec. 31, 2021	Dec. 31, 2020
Property and equipment, gross	$ 7,742	$ 7,463
Accumulated depreciation and amortization	(6,731)	(6,539)
Property and equipment, net	1,011	924
Manufacturing, Laboratory, and Office Equipment [Member]
Property and equipment, gross	4,703	4,591
Leasehold Improvements [Member]
Property and equipment, gross	2,649	2,482
Furniture and Fixtures [Member]
Property and equipment, gross	$ 390	$ 390

Amount of accumulated depreciation, depletion and amortization for physical assets used in the normal conduct of business to produce goods and services.

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