X0306 4 2022-03-04 0000946486 WINDTREE THERAPEUTICS INC /DE/ WINT 0001716213 Hamill John P. 2600 KELLY ROAD SUITE 100 WARRINGTON PA 18976 1 SVP & CFO Common Stock 2022-03-04 4 A 0 66300 0 A 69800 D Employee Stock Option (Right to Buy) 1.02 2022-03-04 4 A 0 99600 0 A 2022-05-31 2032-03-04 Common Stock 99600 99600 D These shares represent restricted stock units (RSUs), which represent a contingent right to receive the equivalent number of shares of common stock. These RSUs shall vest with respect to one-third of the total number of shares subject to the RSUs on an annual basis (every 12 months) with the first vest date on February 28, 2023 provided that the reporting person remains in continuous service on each vesting date. This employee stock option shall vest and become exercisable with respect to one-twelfth of the total number of shares subject to the options on a quarterly basis (every three months) with the first vest date on May 31, 2022 provided that the reporting person remains in continuous service on each vesting date. /s/ John P. Hamill 2022-03-07