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Note 4 - Summary of Significant Accounting Policies (Details Textual) $ / shares in Units, $ in Thousands, shares in Millions			3 Months Ended		12 Months Ended
	Dec. 01, 2020 USD ($)	Jul. 20, 2020 USD ($)	Mar. 31, 2021 USD ($) shares	Mar. 31, 2020 USD ($) shares	Dec. 31, 2020 USD ($)	Mar. 25, 2021 $ / shares	Nov. 01, 2017 USD ($)
Impairment of Intangible Assets, Indefinite-lived (Excluding Goodwill)	$ 0
Number of Reporting Units			1
Goodwill, Impairment Loss					$ 0
Stock and Warrants Issued, Price Per Share (in dollars per share) \| $ / shares						$ 3.25
Foreign Currency Transaction Gain, before Tax			$ 100	$ 200
Liability for Contingent Milestone Payment, Noncurrent			$ 15,000		$ 15,000
Number of Shares of Common Stock Potentially Issuable upon the Exercise of Stock Options and Warrants (in shares) \| shares			19.9	6.5
Deerfield Loan [Member] \| Exchange and Termination Agreement [Member] \| Deerfield Management, L.P. [Member]
Liability for Contingent Milestone Payment, Noncurrent							$ 15,000
John A. Tattory and Kathryn Cole [Member]
Severance Costs		$ 900
Payments for Severance Costs			$ 200
John A. Tattory and Kathryn Cole [Member] \| Employee Severance [Member]
Severance Accrual			$ 300
March 2021 Public Offering [Member]
Stock and Warrants Issued, Price Per Share (in dollars per share) \| $ / shares						$ 3.25