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Note 13 - Restructured Debt Liability (Details Textual) - USD ($)
$ / shares in Units, $ in Thousands
Nov. 01, 2017
Mar. 31, 2020
Dec. 31, 2019
Dec. 31, 2018
Liability for Contingent Milestone Payment, Noncurrent   $ 15,000 $ 15,000 $ 15,000
Deerfield Loan [Member]        
Liability for Contingent Milestone Payment, Noncurrent     15,000 $ 15,000
Deerfield Loan [Member] | Exchange and Termination Agreement [Member] | Deerfield Management, L.P. [Member]        
Extinguishment of Debt, Amount $ 25,000      
Class of Warrant or Right, Number of Warrants Cancelled (in shares) 8,333      
Class of Warrant or Right, Exercise Price of Cancelled Warrants (in dollars per share) $ 2,360.40      
Repayments of Long-term Debt, Total $ 2,500      
Stock Issued During Period, Shares, Cancellation of Debt and Warrant Obligations (in shares) 23,703      
Stock Issued During Period, Shares, Cancellation of Debt and Warrant Obligations, Percentage of Fully-diluted Shares Outstanding 2.00%      
Liability for Contingent Milestone Payment, Noncurrent $ 15,000 $ 15,000 $ 15,000