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Note 22 - Selected Quarterly Financial Data (Unaudited) - Schedule of Quarterly Financial Data (Details) - USD ($)
$ / shares in Units, shares in Thousands
 3 Months Ended 12 Months Ended
Dec. 31, 2019
Sep. 30, 2019
Jun. 30, 2019
Mar. 31, 2019
Dec. 31, 2018
Sep. 30, 2018
Jun. 30, 2018
Mar. 31, 2018
Mar. 31, 2017
Dec. 31, 2019
Dec. 31, 2018
Total revenues     $ 158,000 $ 40,000 $ 304,000 $ 229,000 $ 1,051,000 $ 204,000   $ 198,000 $ 1,788,000
Research and development $ 2,140,000 $ 3,792,000 3,413,000 3,342,000 2,368,000 2,197,000 2,879,000 3,118,000   12,687,000 10,562,000
Selling, general and administrative 2,414,000 3,395,000 3,240,000 3,355,000 2,787,000 1,500,000 1,208,000 1,926,000   12,404,000 7,421,000
Total expenses 4,554,000 7,187,000 6,653,000 6,697,000 5,155,000 3,697,000 4,087,000 5,044,000   25,091,000 17,983,000
Operating loss (4,554,000) (7,187,000) (6,495,000) (6,657,000) (4,851,000) (3,468,000) (3,036,000) (4,840,000)   (24,893,000) (16,195,000)
Other income / (expense), net (2,821,000) 61,000 58,000 120,000 (4,191,000) (459,000) (16,000) 328,000   (2,582,000) (4,338,000)
Net Income (Loss) Attributable to Parent, Total $ (7,375,000) $ (7,126,000) $ (6,437,000) $ (6,537,000) $ (9,042,000) $ (3,927,000) $ (3,052,000) $ (4,512,000)   $ (27,475,000) $ (20,533,000)
Net loss per common share Basic and diluted (in dollars per share) $ (0.64) $ (0.66) $ (0.60) $ (0.61) $ (9.71) $ (3.13) $ (2.44) $ (4.19)   $ (2.51) $ (23.20)
Weighted average number of common shares outstanding Basic and diluted (in shares) 11,532 10,730 10,730 10,714 2,397 1,256 1,250 1,076   10,928 1,498
Grant revenue           $ 70,000 $ 695,000       $ 765,000
AEROSURF warrant dividend         $ (12,505,000)         (12,505,000)
Deemed dividend on preferred stock         (1,718,000)       $ (3,600,000) (1,718,000)
Net (loss) / income attributable to common shareholders         (23,265,000) (3,927,000) (3,052,000) $ (4,512,000)   (27,475,000) (34,756,000)
License [Member]                      
License revenue with affiliate     $ 158,000 $ 40,000 $ 304,000 $ 159,000 $ 356,000 $ 204,000   $ 198,000 $ 1,023,000