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Note 8 - Property and Equipment (Tables)
 12 Months Ended
Dec. 31, 2019
Notes Tables  
Property, Plant and Equipment [Table Text Block]
   
December 31,
  
(in thousands)
  
2019
    
2018
  
                 
Manufacturing, laboratory & office equipment
   $
4,313
     $
4,359
  
Furniture & fixtures
    
390
      
390
  
Leasehold improvements
    
2,469
      
2,469
  
Subtotal
    
7,172
      
7,218
  
Accumulated depreciation and amortization
    
(6,374
 )    
(6,416
 )
Property and equipment, net
   $
798
     $
802