Note 3 - Business Combination (Details Textual) - CVie Investments [Member] $ in Millions	Dec. 31, 2018 USD ($)	Dec. 21, 2018 USD ($) shares
Business Acquisition, Equity Interest Issued or Issuable, Number of Shares \| shares		16,256,060
Business Combination, Consideration Transferred, Total \| $		$ 67.5
Indemnification Agreement, Shares Placed in Escrow \| shares		984,000
Business Combination, Pro Forma Information, Earnings or Loss of Acquiree since Acquisition Date, Actual \| $	$ 0.5
In Process Research and Development [Member]
Indefinite-lived Intangible Assets Acquired \| $		$ 77.1
Warrants Issued for CVie Acquisition [Member]
Business Combination, Ratio of Warrants Received for Each Share of Common Stock and Certain Warrants		0.6148
Class of Warrant or Right, Number of Securities Called by Warrants or Rights \| shares		2,963,167
Warrants and Rights Outstanding, Term		5 years
Class of Warrant or Right, Number of Securities Called by Each Warrant or Right \| shares		1
Warrants and Rights Outstanding \| $		$ 12.5

Number of shares of equity interests issued or issuable to acquire entity.

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Amount of consideration transferred, consisting of acquisition-date fair value of assets transferred by the acquirer, liabilities incurred by the acquirer, and equity interest issued by the acquirer.

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This element represents the amount of earnings or loss of the acquiree since the acquisition date included in the consolidated income statement for the reporting period.

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Number of securities into which each warrant or right may be converted. For example, but not limited to, each warrant may be converted into two shares.

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Number of securities into which the class of warrant or right may be converted. For example, but not limited to, 500,000 warrants may be converted into 1,000,000 shares.

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Amount of increase in assets, excluding financial assets and goodwill, lacking physical substance with an indefinite life, from an acquisition.

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Value of outstanding derivative securities that permit the holder the right to purchase securities (usually equity) from the issuer at a specified price.

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Period between issuance and expiration of outstanding warrant and right embodying unconditional obligation requiring redemption by transferring asset at specified or determinable date or upon event certain to occur, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents reported fact of one year, five months, and thirteen days.

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The ratio of warrants received for each share of common stock and certain warrants held as part of a business combination.

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The number of shares in escrow as part of an indemnification agreement.

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