Consolidated Statements of Changes in Stockholders' Equity - USD ($) $ in Thousands	Private Placement [Member] Preferred Stock [Member]	Private Placement [Member] Common Stock [Member]	Private Placement [Member] Additional Paid-in Capital [Member]	Private Placement [Member] Retained Earnings [Member]	Private Placement [Member] Treasury Stock [Member]	Private Placement [Member]	Share Purchase Agreement [Member] Preferred Stock [Member]	Share Purchase Agreement [Member] Common Stock [Member]	Share Purchase Agreement [Member] Additional Paid-in Capital [Member]	Share Purchase Agreement [Member] Retained Earnings [Member]	Share Purchase Agreement [Member] Treasury Stock [Member]	Share Purchase Agreement [Member]	Share Purchase Agreement, April 2018 [Member] Preferred Stock [Member]	Share Purchase Agreement, April 2018 [Member] Common Stock [Member]	Share Purchase Agreement, April 2018 [Member] Additional Paid-in Capital [Member]	Share Purchase Agreement, April 2018 [Member] Retained Earnings [Member]	Share Purchase Agreement, April 2018 [Member] Treasury Stock [Member]	Share Purchase Agreement, April 2018 [Member]	Share Purchase Agreement, December 2018 [Member] Preferred Stock [Member]	Share Purchase Agreement, December 2018 [Member] Common Stock [Member]	Share Purchase Agreement, December 2018 [Member] Additional Paid-in Capital [Member]	Share Purchase Agreement, December 2018 [Member] Retained Earnings [Member]	Share Purchase Agreement, December 2018 [Member] Treasury Stock [Member]	Share Purchase Agreement, December 2018 [Member]	Placement Agent [Member] Preferred Stock [Member]	Placement Agent [Member] Common Stock [Member]	Placement Agent [Member] Additional Paid-in Capital [Member]	Placement Agent [Member] Retained Earnings [Member]	Placement Agent [Member] Treasury Stock [Member]	Placement Agent [Member]	Warrants in Connection with Equity Consideration in Debt Issuance [Member] Preferred Stock [Member]	Warrants in Connection with Equity Consideration in Debt Issuance [Member] Common Stock [Member]	Warrants in Connection with Equity Consideration in Debt Issuance [Member] Additional Paid-in Capital [Member]	Warrants in Connection with Equity Consideration in Debt Issuance [Member] Retained Earnings [Member]	Warrants in Connection with Equity Consideration in Debt Issuance [Member] Treasury Stock [Member]	Warrants in Connection with Equity Consideration in Debt Issuance [Member]	Warrants in Connection with Equity Consideration in Payable Restructuring [Member] Preferred Stock [Member]	Warrants in Connection with Equity Consideration in Payable Restructuring [Member] Common Stock [Member]	Warrants in Connection with Equity Consideration in Payable Restructuring [Member] Additional Paid-in Capital [Member]	Warrants in Connection with Equity Consideration in Payable Restructuring [Member] Retained Earnings [Member]	Warrants in Connection with Equity Consideration in Payable Restructuring [Member] Treasury Stock [Member]	Warrants in Connection with Equity Consideration in Payable Restructuring [Member]	Preferred Stock [Member]	Common Stock [Member]	Additional Paid-in Capital [Member]	Retained Earnings [Member]	Treasury Stock [Member]	Total
Balance (in shares) at Dec. 31, 2016																																												436,000
Balance at Dec. 31, 2016																																													$ 592,892	$ (618,668)	$ (3,054)	$ (28,830)
Net loss																																														(18,446)		(18,446)
Issuance of stock (in shares)	7,000							2,312,000																																				42,000
Issuance of stock			$ 10,433			$ 10,433		$ 2	$ 9,969			$ 9,971																																	1,030			1,030
Preferred stock conversions (in shares)																																											(4,000)	217,000
Preferred stock conversions																																													(2)			(2)
Issuance of common stock, 401(k) plan employer match (in shares)																																												7,000
Issuance of common stock, 401(k) plan employer match																																													95			95
Issuance of common stock, equity consideration in debt restructuring (in shares)																																												71,000
Issuance of common stock, equity consideration in debt restructuring																																													267			267
Exercise of prefunded common stock warrants (in shares)																																												142,000
Exercise of prefunded common stock warrants
Stock-based compensation expense																																												$ 1	1,561			$ 1,562
Balance (in shares) at Dec. 31, 2017																																											3,000	3,227,000				3,227,421
Balance at Dec. 31, 2017																																												$ 3	616,245	(637,114)	$ (3,054)	$ (23,920)
Net loss																																														(20,533)		(20,533)
Issuance of stock (in shares)														542,000						11,786,000						114,000
Issuance of stock														$ 1	$ 2,540			$ 2,541		$ 12	$ 41,101			$ 41,113
Preferred stock conversions (in shares)																																											(3,000)	135,000
Preferred stock conversions
Stock-based compensation expense																																													955			955
Issuance of common stock, CVie Acquisition (in shares)																																												16,265,000
Issuance of common stock, CVie Acquisition																																												$ 16	67,484			67,500
Vesting of restricted stock units (in shares)																																												95,000
Vesting of restricted stock units
Withholding tax payments related to net share settlements of restricted stock units (in shares)																																												(31,000)
Withholding tax payments related to net share settlements of restricted stock units																																													(155)			$ (155)
Issuance of warrants																																	$ 417			$ 417			$ 196			$ 196
Stock-based compensation expense (in shares)
Balance (in shares) at Dec. 31, 2018																																												32,133,000				32,133,189
Balance at Dec. 31, 2018																																												$ 32	$ 728,783	$ (657,647)	$ (3,054)	$ 68,114