Note 3 - Business Combination - Pro Forma Information (Details) - CVie Investments [Member] - USD ($) $ / shares in Units, $ in Thousands	12 Months Ended
Dec. 31, 2018	Dec. 31, 2017
Pro forma net loss attributable to common shareholders	$ (38,082)	$ (34,616)
Pro forma EPS - basic and diluted (in dollars per share)	$ (1.20)	$ (1.19)

The pro forma net Income or Loss for the period as if the business combination or combinations had been completed at the beginning of a period.

Reference 1: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 805
-SubTopic 10
-Section 50
-Paragraph 2
-Subparagraph (h)(3)
-URI http://asc.fasb.org/extlink&oid=79982066&loc=d3e1392-128463

Reference 2: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 805
-SubTopic 10
-Section 50
-Paragraph 2
-Subparagraph (h)(2)
-URI http://asc.fasb.org/extlink&oid=79982066&loc=d3e1392-128463

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Namespace Prefix:	us-gaap_
Data Type:	xbrli:monetaryItemType
Balance Type:	credit
Period Type:	duration