Note 20 - Income Taxes (Tables)

12 Months Ended

Dec. 31, 2018

Notes Tables

Schedule of Effective Income Tax Rate Reconciliation [Table Text Block]

	December 31,
(in thousands)	2018			2017
Income tax benefit, statutory rates	$	(4,312	)	$	(6,272	)
State taxes on income, net of federal benefit		(535	)		(398	)
Impact of tax reform		5			71,151
Research and development tax credit		(351	)		(797	)
Foreign rate differential		24			-
Employee related		2,875			953
Interest related		186			(147	)
Income tax expense / (benefit), statutory rates		(2,108	)		64,490
Valuation allowance		2,108			(64,490	)
Income tax benefit, net	$	-		$	-

Schedule of Deferred Tax Assets and Liabilities [Table Text Block]

	December 31,
(in thousands)	2018			2017
Long-term deferred assets:
Net operating loss carryforwards (federal and state)	$	176,759		$	168,263
Research and development tax credit		16,718			16,813
Compensation expense on stock		1,121			1,191
Charitable contribution carryforward		-			5
Other accrued		1,016			2,547
Deferred revenue		57			317
Depreciation		309			297
Total long-term deferred tax assets		195,980			189,433
Long-term deferred liabilities:
IPR&D		(15,476	)		-
Total long-term deferred tax liabilities		(15,476	)		-
Valuation allowance		(195,980	)		(189,433	)
Deferred tax liabilities, net	$	(15,476	)	$	-