Stockholders' Equity, Registered Public Offerings (Details) - USD ($) $ / shares in Units, $ in Thousands		12 Months Ended
	Jul. 22, 2015	Dec. 31, 2015	Dec. 31, 2014
Stockholders' Equity [Line Items]
Exercise price of warrants (in dollars per share)		$ 39.34
Common Stock [Member]
Stockholders' Equity [Line Items]
Issuance of common stock, July 2015 financing (in shares)		1,792,000
2011 Warrants [Member]
Stockholders' Equity [Line Items]
Exercise price of warrants (in dollars per share)		$ 2.66	$ 21.00
Registered Public Offerings [Member]
Stockholders' Equity [Line Items]
Gross proceeds from issuance of units	$ 40,250
Net proceeds from issuance of common stock	$ 37,600
Class of warrants may not exercise to extent	9.99%
Class of warrants exercise may be elected by holders	4.99%
Registered Public Offerings [Member] | Deerfield Debt Restructuring [Member]
Stockholders' Equity [Line Items]
Non-cash consideration received	$ 5,000
Registered Public Offerings [Member] | Series A Units [Member]
Stockholders' Equity [Line Items]
Issuance of common stock, July 2015 financing (in shares)	1,791,667
Sale of unit price per unit (in dollars per unit)	$ 8.40
Number of warrants required to purchase one share of common stock (in shares)	1
Exercise price of warrants (in dollars per share)	$ 8.40
Registered Public Offerings [Member] | Series A Warrant [Member]
Stockholders' Equity [Line Items]
Number of warrants required to purchase one share of common stock (in shares)	1
Exercise price of warrants (in dollars per share)	$ 9.80
Registered Public Offerings [Member] | Series B Units [Member]
Stockholders' Equity [Line Items]
Issuance of common stock, July 2015 financing (in shares)	3,000,000
Sale of unit price per unit (in dollars per unit)	$ 8.40
Number of warrants required to purchase one share of common stock (in shares)	1
Exercise price of warrants (in dollars per share)	$ 8.40
Registered Public Offerings [Member] | Series B Warrant [Member]
Stockholders' Equity [Line Items]
Number of warrants required to purchase one share of common stock (in shares)	1
Exercise price of warrants (in dollars per share)	$ 9.80
Over-Allotment [Member] | Series A Units [Member]
Stockholders' Equity [Line Items]
Issuance of common stock, July 2015 financing (in shares)	625,000