DISCOVERY LABORATORIES, INC.

2600 Kelly Rd, Suite 100

Warrington, PA 18976

P - 215.488.9300

F - 215.488.9557

www.discoverylabs.com

June 19, 2013

Jeffrey Riedler, Assistant Director

Division of Corporation Finance

United States Securities and Exchange Commission

100 F Street, NE

Washington, D.C. 20549

Re:Discovery Laboratories, Inc.

Registration Statement on Form S-3

Filed April 15, 2013 (File No. 333-187934)

Dear Mr. Riedler:

Pursuant to Rule 461 of Regulation C promulgated under the Securities Act of 1933, Discovery Laboratories, Inc., a Delaware corporation (the “Company”), hereby requests that the effectiveness of the Company’s Registration Statement on Form S-3, File No. 333-187934, be accelerated to 4:30 p.m. (New York time), June 20, 2013, or as soon thereafter as is practicable.

Very truly yours,

DISCOVERY LABORATORIES, INC.

/s/ Mary B. Templeton

Mary B. Templeton

Senior Vice President, General Counsel and

Corporate Secretary

Cc: Ira L. Kotel