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Stock Options and Stock-based Employee Compensation (Tables)
12 Months Ended
Dec. 31, 2012
Stock Options and Stock-based Employee Compensation [Abstract]  
Option Activity
A summary of activity under our long-term incentive plans is presented below:
 
(in thousands, except for weighted-average data)
      
Weighted-
Average
 
Weighted-
Average
Remaining
Stock Options
  
Shares
   
 Exercise
Price
 
Contractual
Term (In Yrs)
          
Outstanding at December 31, 2009
  1,065  $56.46  
           
Granted
  20   3.19  
Exercised
       
Forfeited or expired
  (142)  51.93  
Outstanding at December 31, 2010
  943  $56.06  
           
Granted
  1,771   1.84  
Exercised
       
Forfeited or expired
  (276)  44.95  
Outstanding at December 31, 2011
  2,438  $17.97  
           
Granted
  1,724   2.63  
Exercised
  (3)  1.83  
Forfeited or expired
  (162)  24.39  
Outstanding at December 31, 2012
  3,997  $11.11 
7.9
           
Exercisable at December 31, 2012
  1,654  $23.53 
6.9
Nonvested Option Activity
A summary of nonvested shares issuable upon exercise of outstanding options and changes during 2012 is presented below:
 
(shares in thousands) 
Option
Shares
  
Weighted-
Average Grant-
Date Fair Value
 
       
Non-vested at December 31, 2011
  1,771  $1.85 
Granted
  1,724   2.63 
Vested
  (1,087)  2.04 
Forfeited
  (65)  2.37 
Non-vested at December 31, 2012
  2,343  $2.33 
Options Outstanding, Vested and Exercisable
The following table provides detail with regard to options outstanding, vested and exercisable at December 31, 2012:
 
(shares in thousands)
  Outstanding 
Vested and Exercisable
Price per share
  
Shares
  
Weighted-
Average Price
per Share
 
Weighted- Average Remaining Contractual Life
 
Shares
  
Weighted-
Average Price
per Share
 
Weighted- Average Remaining Contractual Life
$1.58 - $156.45   3,997  $11.11 
7.9 Years
  1,654  $23.53 
6.9 Years
Employee stock-based compensation
Stock-based compensation expense was classified as follows:

   
December 31,
 
(in thousands)
 
2012
  
2011
  
2010
 
           
Research and development
 $487  $289  $479 
Selling, General and administrative
  1,924   578   931 
Total
 $2,411  $867  $1,410 
Weighted-average assumptions in estimating fair value of options
The fair value of each option award is estimated on the date of grant using the Black-Scholes option-pricing formula that uses assumptions noted in the following table.  Expected volatilities are based upon the historical volatility of our common stock and other factors.  We also use historical data and other factors to estimate option exercises, employee terminations and forfeiture rates within the valuation model.  The risk-free interest rates are based upon the U.S. Treasury yield curve in effect at the time of the grant.

   
December 31,
 
   
2012
  
2011
  
2010
 
           
Weighted average expected volatility
 111%  113%  112% 
Weighted average expected term
 
4.6 years
  
4.8 years
  
4.9 years
 
Weighted average risk-free interest rate
 0.74%  1.08%  1.47% 
Expected dividends