Exhibit 32.1

PROTHERICS PLC

CERTIFICATIONS PURSUANT TO RULE 13a-14(b) OF THE SECURITIES EXCHANGE
ACT OF 1934, AS AMENDED, AND 18 U.S.C. §1350, AS ADOPTED PURSUANT TO
SECTION 906 OF THE SARBANES-OXLEY ACT OF 2002

     In connection with the Report of Protherics PLC (the “Company”) on Form 20-F for the year ended March 31, 2008, as filed with the Securities and Exchange Commission (the “SEC”) on the date hereof (the “Report”), Andrew J. Heath, Chief Executive Officer of the Company, and Rolf Soderstrom, Chief Financial Officer of the Company, certify, pursuant to Section 906 of the Sarbanes-Oxley Act of 2002 (subsections (a) and (b) of Section 1350, Chapter 63 of Title 18, United States Code) that:

     (1) The Report fully complies with the requirements of Section 13(a) or 15(d) of the Securities Exchange Act of 1934 (the “Exchange Act”); and

     (2) Information contained in the Report fairly presents, in all material respects, the financial condition and results of operations of the Company.

Date: July 31, 2008	/s/ Andrew J. Heath
	Andrew J. Heath
	Chief Executive Officer
	/s/ R. Soderstrom
	Rolf Soderstrom
	Chief Financial Officer